Technology Process of (-)-(S)-2-phenyl-N-tosyl-2-trifluoromethylaziridine
There total 5 articles about (-)-(S)-2-phenyl-N-tosyl-2-trifluoromethylaziridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran;
at 20 ℃;
for 5h;
optical yield given as %ee;
Inert atmosphere;
DOI:10.1039/c0ob00690d
- Guidance literature:
-
Multi-step reaction with 4 steps
1: titanium tetrachloride; triethylamine / dichloromethane / 3.08 h / 0 - 20 °C / Inert atmosphere
2: sodium tris(acetoxy)borohydride / 15 h
3: palladium 10% on activated carbon; ammonium formate / methanol / 2 h / Reflux
4: triethylamine; triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere
With
palladium 10% on activated carbon; ammonium formate; titanium tetrachloride; sodium tris(acetoxy)borohydride; triethylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; dichloromethane;
4: Mitsunobu type cyclisation;
DOI:10.1039/c0ob00690d
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium tris(acetoxy)borohydride / 15 h
2: palladium 10% on activated carbon; ammonium formate / methanol / 2 h / Reflux
3: triethylamine; triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere
With
palladium 10% on activated carbon; ammonium formate; sodium tris(acetoxy)borohydride; triethylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol;
3: Mitsunobu type cyclisation;
DOI:10.1039/c0ob00690d
