N-(tert-butyloxycarbonyl)-L-aspartic acid β-benzyl-α-(trimethylsilyl)ethyl diester

Base Information

Chemical Name:N-(tert-butyloxycarbonyl)-L-aspartic acid β-benzyl-α-(trimethylsilyl)ethyl diester
CAS No.:123836-67-9
Molecular Formula:C₂₁H₃₃NO₆Si
Molecular Weight:423.582
Hs Code.:

Synonyms:N-(tert-butyloxycarbonyl)-L-aspartic acid β-benzyl-α-(trimethylsilyl)ethyl diester

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Chemical Property of N-(tert-butyloxycarbonyl)-L-aspartic acid β-benzyl-α-(trimethylsilyl)ethyl diester

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Technology Process of N-(tert-butyloxycarbonyl)-L-aspartic acid β-benzyl-α-(trimethylsilyl)ethyl diester

There total 1 articles about N-(tert-butyloxycarbonyl)-L-aspartic acid β-benzyl-α-(trimethylsilyl)ethyl diester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 7536-58-5,98482-77-0
BOC-L-aspartic acid 4-benzyl ester

: 123836-67-9
N-(tert-butyloxycarbonyl)-L-aspartic acid β-benzyl-α-(trimethylsilyl)ethyl diester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 5h; Ambient temperature;
DOI:10.1021/jo00290a026

Reference yield: 67.0%

: 123836-67-9
N-(tert-butyloxycarbonyl)-L-aspartic acid β-benzyl-α-(trimethylsilyl)ethyl diester

: 123836-78-2
L-aspartic acid β-benzyl-α-(trimethylsilyl)ethyl diester hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 2h; Ambient temperature;
DOI:10.1021/jo00290a026

Reference yield:

: 123836-67-9
N-(tert-butyloxycarbonyl)-L-aspartic acid β-benzyl-α-(trimethylsilyl)ethyl diester

: 123930-12-1
3-(carbobenzyloxy)-2(S)-(3(S)-((tert-butyloxycarbonyl)amino)-4(R)-n-propyl-2-oxo-1-pyrrolidinyl)propanoic acid (trimethylsilyl)ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 2) 5N HCl, MeOH / cyclohexane, 1) 40 deg C, 18 h, 2) RT, 5 min

2: 77 percent / diisopropylethylamine / acetone / 16 h / Ambient temperature

3: 66 percent / decahydronaphthalene / 1 h / Heating

4: 75 percent / H₂ / 5percent Pd/BaSO₄ / ethyl acetate / 7 h / 760 Torr

5: 31 percent / sodium acetate, NaBH₃CN / ethanol / 1) RT, 24 h, 2) 50 deg C, 24 h

With hydrogenchloride; methanol; hydrogen; sodium acetate; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; Pd-BaSO₄; In ethanol; ethyl acetate; acetone; decalin;
DOI:10.1021/jo00290a026