4-oxo-4-(benzyloxy)-3-(hydroxymethylene)-2(S)-((tert-butyloxycarbonyl)amino)butanoic acid (trimethylsilyl)-ethyl ester

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Chemical Name:4-oxo-4-(benzyloxy)-3-(hydroxymethylene)-2(S)-((tert-butyloxycarbonyl)amino)butanoic acid (trimethylsilyl)-ethyl ester
CAS No.:123836-68-0
Molecular Formula:C₂₂H₃₃NO₇Si
Molecular Weight:451.592
Hs Code.:

Synonyms:4-oxo-4-(benzyloxy)-3-(hydroxymethylene)-2(S)-((tert-butyloxycarbonyl)amino)butanoic acid (trimethylsilyl)-ethyl ester

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Chemical Property of 4-oxo-4-(benzyloxy)-3-(hydroxymethylene)-2(S)-((tert-butyloxycarbonyl)amino)butanoic acid (trimethylsilyl)-ethyl ester

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Technology Process of 4-oxo-4-(benzyloxy)-3-(hydroxymethylene)-2(S)-((tert-butyloxycarbonyl)amino)butanoic acid (trimethylsilyl)-ethyl ester

There total 3 articles about 4-oxo-4-(benzyloxy)-3-(hydroxymethylene)-2(S)-((tert-butyloxycarbonyl)amino)butanoic acid (trimethylsilyl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 123836-68-0
4-oxo-4-(benzyloxy)-3-(hydroxymethylene)-2(S)-((tert-butyloxycarbonyl)amino)butanoic acid (trimethylsilyl)-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / 4-(dimethylamino)pyridine, 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 5 h / Ambient temperature

2: 2) 5N HCl, MeOH / cyclohexane, 1) 40 deg C, 18 h, 2) RT, 5 min

With hydrogenchloride; methanol; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/jo00290a026

Reference yield:

: 7536-58-5,98482-77-0
BOC-L-aspartic acid 4-benzyl ester

: 123836-68-0
4-oxo-4-(benzyloxy)-3-(hydroxymethylene)-2(S)-((tert-butyloxycarbonyl)amino)butanoic acid (trimethylsilyl)-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / 4-(dimethylamino)pyridine, 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 5 h / Ambient temperature

2: 2) 5N HCl, MeOH / cyclohexane, 1) 40 deg C, 18 h, 2) RT, 5 min

With hydrogenchloride; methanol; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/jo00290a026

Reference yield:

: 5815-08-7
tert-Butoxybis(dimethylamino)methane

: 123836-67-9
N-(tert-butyloxycarbonyl)-L-aspartic acid β-benzyl-α-(trimethylsilyl)ethyl diester

: 123836-68-0
4-oxo-4-(benzyloxy)-3-(hydroxymethylene)-2(S)-((tert-butyloxycarbonyl)amino)butanoic acid (trimethylsilyl)-ethyl ester

Guidance literature:: With hydrogenchloride; methanol; Yield given. Multistep reaction; cyclohexane, 1) 40 deg C, 18 h, 2) RT, 5 min;
DOI:10.1021/jo00290a026