(4S,5S,E)-7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-4-methylhept-2-en-1-ol

Base Information

Chemical Name:(4S,5S,E)-7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-4-methylhept-2-en-1-ol
CAS No.:1252009-22-5
Molecular Formula:C₂₁H₃₆O₃Si
Molecular Weight:364.601
Hs Code.:

Synonyms:(4S,5S,E)-7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-4-methylhept-2-en-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,5S,E)-7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-4-methylhept-2-en-1-ol

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Technology Process of (4S,5S,E)-7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-4-methylhept-2-en-1-ol

There total 3 articles about (4S,5S,E)-7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-4-methylhept-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1252009-20-3
(4S,5S,E)-ethyl 7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-4-methylhept-2-enoate

: 1252009-22-5
(4S,5S,E)-7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-4-methylhept-2-en-1-ol

Guidance literature:: With diisobutylaluminium hydride; In hexane; dichloromethane; for 1h; Cooling;
DOI:10.1039/c8ob00388b

Reference yield:

: 872369-16-9
(?)-(2S,3S)-5-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-2-methylpentan-1-ol

: 1252009-22-5
(4S,5S,E)-7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-4-methylhept-2-en-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 1 h / Reflux

2: benzene / 80 °C

3: diisobutylaluminium hydride / dichloromethane; hexane / 1 h / Cooling

With diisobutylaluminium hydride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In hexane; dichloromethane; acetonitrile; benzene; 2: |Wittig Olefination;
DOI:10.1039/c8ob00388b

Reference yield:

: 872369-17-0
(2R,3S)-5-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-2-methylpentanal

: 1252009-22-5
(4S,5S,E)-7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-4-methylhept-2-en-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: benzene / 80 °C

2: diisobutylaluminium hydride / dichloromethane; hexane / 1 h / Cooling

With diisobutylaluminium hydride; In hexane; dichloromethane; benzene; 1: |Wittig Olefination;
DOI:10.1039/c8ob00388b