(4R,5S)-t-butyl 4-hydroxy-5-(4-methylphenyl)thio decanoate

Base Information

Chemical Name:(4R,5S)-t-butyl 4-hydroxy-5-(4-methylphenyl)thio decanoate
CAS No.:115352-59-5
Molecular Formula:C₂₁H₃₄O₃S
Molecular Weight:366.565
Hs Code.:

Synonyms:(4R,5S)-t-butyl 4-hydroxy-5-(4-methylphenyl)thio decanoate

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Chemical Property of (4R,5S)-t-butyl 4-hydroxy-5-(4-methylphenyl)thio decanoate

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Technology Process of (4R,5S)-t-butyl 4-hydroxy-5-(4-methylphenyl)thio decanoate

There total 6 articles about (4R,5S)-t-butyl 4-hydroxy-5-(4-methylphenyl)thio decanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 115405-24-8
(4R,5S,R_S)-t-butyl-5-(4-methylphenyl)sulphinyl decanoate

: 115352-59-5
(4R,5S)-t-butyl 4-hydroxy-5-(4-methylphenyl)thio decanoate

Guidance literature:: With trifluoroacetic acid; sodium iodide; In acetone; at -50 - -20 ℃;
DOI:10.1016/S0040-4020(01)86906-4

Reference yield:

: 14734-25-9
succinic acid (methyl)(tert-butyl)diester

: 115352-59-5
(4R,5S)-t-butyl 4-hydroxy-5-(4-methylphenyl)thio decanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) THF, -78 deg C 2.) THF, -78 deg C, 10 min.

2: 34 percent / NaBH₄, aq. NH₃ / methanol / 0.17 h / Ambient temperature; further reag.: DIBAH, DIBAH with ZnCl₂ or CdCl₂ in THF, hexane at -78 deg C

3: 82 percent / trifluoroacetic acid, sodium iodide / acetone / -50 - -20 °C

With ammonium hydroxide; sodium tetrahydroborate; trifluoroacetic acid; sodium iodide; lithium diisopropyl amide; In methanol; acetone;
DOI:10.1016/S0040-4020(01)86906-4

Reference yield:

: 1517-82-4
(1R,2S,5R,SS)-(-)-menthyl p-toluenesulfinate

: 115352-59-5
(4R,5S)-t-butyl 4-hydroxy-5-(4-methylphenyl)thio decanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Mg, iodine / 1.) ether, 2 h 2.) benzene, RT, 30 min.

2: 1.) LDA / 1.) THF, -78 deg C 2.) THF, -78 deg C, 10 min.

3: 34 percent / NaBH₄, aq. NH₃ / methanol / 0.17 h / Ambient temperature; further reag.: DIBAH, DIBAH with ZnCl₂ or CdCl₂ in THF, hexane at -78 deg C

4: 82 percent / trifluoroacetic acid, sodium iodide / acetone / -50 - -20 °C

With ammonium hydroxide; sodium tetrahydroborate; iodine; magnesium; trifluoroacetic acid; sodium iodide; lithium diisopropyl amide; In methanol; acetone;
DOI:10.1016/S0040-4020(01)86906-4