2-(6-benzyloxymethyl-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)propionic acide ethyl ester

Base Information

Chemical Name:2-(6-benzyloxymethyl-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)propionic acide ethyl ester
CAS No.:582313-73-3
Molecular Formula:C₂₀H₂₈O₆
Molecular Weight:364.439
Hs Code.:

Synonyms:2-(6-benzyloxymethyl-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)propionic acide ethyl ester

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Chemical Property of 2-(6-benzyloxymethyl-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)propionic acide ethyl ester

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Technology Process of 2-(6-benzyloxymethyl-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)propionic acide ethyl ester

There total 1 articles about 2-(6-benzyloxymethyl-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)propionic acide ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 85846-80-6
5-O-benzyl-2,3-O-isopropylidene-D-ribono-1,4-lactone

: 21382-82-1
(carbethoxyethylidene)triphenylphosphorane

: 582313-73-3
2-(6-benzyloxymethyl-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)propionic acide ethyl ester

Guidance literature:: 5-O-benzyl-2,3-O-isopropylidene-D-ribono-1,4-lactone; With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 3h;

(carbethoxyethylidene)triphenylphosphorane; In toluene; at 110 ℃;

With potassium tert-butylate; In toluene; at 20 ℃;
DOI:10.1248/cpb.51.276

Reference yield: 32.7%

: 582313-73-3
2-(6-benzyloxymethyl-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)propionic acide ethyl ester

: 582313-74-4
2-(6-benzyloxymethyl-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)propionic-1-ol

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 1h;
DOI:10.1248/cpb.51.276

Reference yield:

: 582313-73-3
2-(6-benzyloxymethyl-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)propionic acide ethyl ester

: 582313-75-5
4-[2-(6-benzyloxymethyl-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)propoxy]benzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 32.7 percent / DIBAL-H / CH₂Cl₂ / 1 h / -78 °C

2: 51 percent / diethyl azodicarboxylate; Ph₃P / tetrahydrofuran / 48 h

With diisobutylaluminium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 2: Mitsunobu reaction;
DOI:10.1248/cpb.51.276