carbonic acid allyl ester (2R,3R)-2-tert-butoxycarbonylamino-3-fluoro-3-phenylpropyl ester

Base Information

Chemical Name:carbonic acid allyl ester (2R,3R)-2-tert-butoxycarbonylamino-3-fluoro-3-phenylpropyl ester
CAS No.:1132645-28-3
Molecular Formula:C₁₈H₂₄FNO₅
Molecular Weight:353.391
Hs Code.:

Synonyms:carbonic acid allyl ester (2R,3R)-2-tert-butoxycarbonylamino-3-fluoro-3-phenylpropyl ester

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Chemical Property of carbonic acid allyl ester (2R,3R)-2-tert-butoxycarbonylamino-3-fluoro-3-phenylpropyl ester

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Technology Process of carbonic acid allyl ester (2R,3R)-2-tert-butoxycarbonylamino-3-fluoro-3-phenylpropyl ester

There total 4 articles about carbonic acid allyl ester (2R,3R)-2-tert-butoxycarbonylamino-3-fluoro-3-phenylpropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1132645-27-2
tert-butyl (1R,2R)-3-(allyloxycarbonyloxy)-1-hydroxy-1-phenylpropan-2-ylcarbamate

: 1132645-28-3
carbonic acid allyl ester (2R,3R)-2-tert-butoxycarbonylamino-3-fluoro-3-phenylpropyl ester

Guidance literature:: With diethylamino-sulfur trifluoride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 - 20 ℃; for 19h; Inert atmosphere;
DOI:10.1021/jo802611t

Reference yield:

: 46032-98-8
(1R,2R)-2-amino-1-phenylpropane-1,3-diol

: 1132645-28-3
carbonic acid allyl ester (2R,3R)-2-tert-butoxycarbonylamino-3-fluoro-3-phenylpropyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / 2 h / 20 °C

2: pyridine / dichloromethane / 1 h / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine; diethylamino-sulfur trifluoride / dichloromethane / 2 h / -78 - 20 °C / Inert atmosphere

With pyridine; diethylamino-sulfur trifluoride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;

Reference yield:

: 1009093-14-4
((1R,2R)-2-hydroxy-1-hydroxymethyl-2-phenylethyl)carbamic acid tert-butyl ester

: 1132645-28-3
carbonic acid allyl ester (2R,3R)-2-tert-butoxycarbonylamino-3-fluoro-3-phenylpropyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 1 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine; diethylamino-sulfur trifluoride / dichloromethane / 2 h / -78 - 20 °C / Inert atmosphere

With pyridine; diethylamino-sulfur trifluoride; N-ethyl-N,N-diisopropylamine; In dichloromethane;