3β-(3,4-dichlorophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid 2-aminoethyl ester

Base Information

• Chemical Name: 3β-(3,4-dichlorophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid 2-aminoethyl ester
• CAS No.: 872460-76-9
• Molecular Formula: C₁₇H₂₂Cl₂N₂O₂
• Molecular Weight: 357.28
• Mol file: 872460-76-9.mol

Synonyms:3β-(3,4-dichlorophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid 2-aminoethyl ester

Chemical Property of 3β-(3,4-dichlorophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid 2-aminoethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3β-(3,4-dichlorophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid 2-aminoethyl ester

There total 4 articles about 3β-(3,4-dichlorophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid 2-aminoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

3β-(3,4-dichlorophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)ethyl ester (872460-75-8) → 3β-(3,4-dichlorophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid 2-aminoethyl ester (872460-76-9)

Guidance literature:

With hydrazine; In ethanol; for 1.5h; Heating;

DOI:10.1021/jm050431y

Reference yield:

dicholoropane (143965-99-5) → 3β-(3,4-dichlorophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid 2-aminoethyl ester (872460-76-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 73 percent / H₂O / dioxane / 17 h / Heating

2: POCl₃ / 4 h / 20 °C

3: 459 mg / Et₃N / CH₂Cl₂ / 17 h / 20 °C

4: 76 percent / hydrazine / ethanol / 1.5 h / Heating

With water; triethylamine; hydrazine; trichlorophosphate; In 1,4-dioxane; ethanol; dichloromethane;

DOI:10.1021/jm050431y

Reference yield:

(1R,2S,3S,5S)-3-(3,4-Dichloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carbonyl chloride → 3β-(3,4-dichlorophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid 2-aminoethyl ester (872460-76-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 459 mg / Et₃N / CH₂Cl₂ / 17 h / 20 °C

2: 76 percent / hydrazine / ethanol / 1.5 h / Heating

With triethylamine; hydrazine; In ethanol; dichloromethane;

DOI:10.1021/jm050431y

upstream raw materials:

3β-(3,4-dichlorophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)ethyl ester

dicholoropane

3β-(3,4-dichlorophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid