3β-(3,4-dichlorophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)ethyl ester

Base Information

• Chemical Name: 3β-(3,4-dichlorophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)ethyl ester
• CAS No.: 872460-75-8
• Molecular Formula: C₂₅H₂₄Cl₂N₂O₄
• Molecular Weight: 487.383
• Mol file: 872460-75-8.mol

Synonyms:3β-(3,4-dichlorophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)ethyl ester

Chemical Property of 3β-(3,4-dichlorophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3β-(3,4-dichlorophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)ethyl ester

There total 3 articles about 3β-(3,4-dichlorophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2-Hydroxyethyl)phthalimide (3891-07-4) + (1R,2S,3S,5S)-3-(3,4-Dichloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carbonyl chloride → 3β-(3,4-dichlorophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)ethyl ester (872460-75-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 17h;

DOI:10.1021/jm050431y

Reference yield:

dicholoropane (143965-99-5) → 3β-(3,4-dichlorophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)ethyl ester (872460-75-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / H₂O / dioxane / 17 h / Heating

2: POCl₃ / 4 h / 20 °C

3: 459 mg / Et₃N / CH₂Cl₂ / 17 h / 20 °C

With water; triethylamine; trichlorophosphate; In 1,4-dioxane; dichloromethane;

DOI:10.1021/jm050431y

Reference yield:

3β-(3,4-dichlorophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid (306740-52-3) → 3β-(3,4-dichlorophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)ethyl ester (872460-75-8)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃ / 4 h / 20 °C

2: 459 mg / Et₃N / CH₂Cl₂ / 17 h / 20 °C

With triethylamine; trichlorophosphate; In dichloromethane;

DOI:10.1021/jm050431y

upstream raw materials:

N-(2-Hydroxyethyl)phthalimide

dicholoropane

3β-(3,4-dichlorophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid

Downstream raw materials:

3β-(3,4-dichlorophenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid 2-aminoethyl ester