Fosfluridine Tidoxil

Base Information

Chemical Name:Fosfluridine Tidoxil
CAS No.:174638-15-4
Molecular Formula:C₃₄H₆₂FN₂O₁₀PS
Molecular Weight:740.912
Hs Code.:
UNII:VY3U311S3Q
Wikidata:Q27292090
NCI Thesaurus Code:C170009
ChEMBL ID:CHEMBL2107800
Mol file:174638-15-4.mol

Synonyms:Fosfluridine Tidoxil;Fosfluridine Tidoxil [INN];174638-15-4;UNII-VY3U311S3Q;VY3U311S3Q;5-Fluorouridine 5'-((2RS)-2-(decyloxy)-3-(dodecylsulfanyl)propyl hydrogen phosphate);2-(decyloxy)-3-(dodecylthio)propyl (((2R,3S,4R,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl) hydrogen phosphate;Fosfluridine;D03BTP;SCHEMBL7524603;CHEMBL2107800;AKOS040748374;HDP-99-0006;5-fluorouridine prodrug, Heidelberg Pharma;Q27292090;5'-URIDYLIC ACID, 5-FLUORO-, MONO(2-(DECYLOXY)-3-(DODECYLTHIO)PROPYL) ESTER;(2-decoxy-3-dodecylsulfanylpropyl) [(2R,3S,4R,5R)-5-(5-fluoro-2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate

Suppliers and Price of Fosfluridine Tidoxil

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Fosfluridine Tidoxil

Chemical Property:

PSA：204.91000
LogP:7.02080
XLogP3:7.5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:30
Exact Mass:740.38468251
Heavy Atom Count:49
Complexity:1010

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCCCCCCCCSCC(COP(=O)(O)OCC1C(C(C(O1)N2C=C(C(=O)NC2=O)F)O)O)OCCCCCCCCCC
Isomeric SMILES:CCCCCCCCCCCCSCC(COP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=C(C(=O)NC2=O)F)O)O)OCCCCCCCCCC
Recent EU Clinical Trials:A Multi-Centre Double-Blind Randomised Placebo-Controlled Phase II Study of HDP 99.0006 in Patients with Actinic Keratosis

Technology Process of Fosfluridine Tidoxil

There total 3 articles about Fosfluridine Tidoxil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 316-46-1
5-fluorouridine

: 153952-84-2
1-dodecylthio-2-decyloxypropyl-3-phosphatidic acid

: 174638-15-4
(5-fluorouridine)-5'-phosphoric acid (3-dodecylthio-2-decyloxy)propyl ester

Guidance literature:: 5-fluorouridine; 1-dodecylthio-2-decyloxypropyl-3-phosphatidic acid; With pyridine; 2,4,6-triisopropylbenzenesulfonic acid chloride; In pyridine; at 20 ℃; for 24h;

With water; at 20 ℃; for 2h;

Reference yield:

: 2797-17-3
2',3'-O-isopropylidene-5-fluorouridine

: 174638-15-4
(5-fluorouridine)-5'-phosphoric acid (3-dodecylthio-2-decyloxy)propyl ester

Guidance literature:: 1-dodecylthio-2-decyloxypropyl-3-phosphatidic acid; With 2,4,6-triisopropylphenylsulfonyl chloride; In pyridine; at 20 - 25 ℃; for 2h;

2',3'-O-isopropylidene-5-fluorouridine; In pyridine; at 20 - 25 ℃; for 16h;