(1'S)-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzyl alcohol

Base Information

• Chemical Name: (1'S)-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzyl alcohol
• CAS No.: 222022-92-6
• Molecular Formula: C₁₇H₂₆O₃
• Molecular Weight: 278.392
• Mol file: 222022-92-6.mol

Synonyms:(1'S)-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzyl alcohol

Chemical Property of (1'S)-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzyl alcohol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1'S)-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzyl alcohol

There total 4 articles about (1'S)-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(1'S)-3,4-Dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzaldehyde (222022-91-5) → (1'S)-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzyl alcohol (222022-92-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1016/S0040-4039(98)02487-3

Reference yield:

(1'S)-3,4-dihydroxy-5-(1,2,2-trimethylcyclopentyl)benzaldehyde (185967-11-7) → (1'S)-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzyl alcohol (222022-92-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / K₂CO₃ / acetone

2: 72 percent / LiAlH₄ / tetrahydrofuran / 2 h

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; acetone;

DOI:10.1021/ja001455r

Reference yield:

(S)-5-bromomethyl-1,2-dimethoxy-3-(1,2,2-trimethylcyclopentyl)benzene → (1'S)-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzyl alcohol (222022-92-6)

Guidance literature:

With water; calcium carbonate; In 1,4-dioxane; Heating;

DOI:10.1016/S0040-4020(00)01131-5

upstream raw materials:

(1'S)-3,4-Dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzaldehyde

(1'S)-3,4-dihydroxy-5-(1,2,2-trimethylcyclopentyl)benzaldehyde

(1'S)-1,2-dimethoxy-5-methyl-3-(1',2',2'-trimethylcyclopentyl)benzene

Downstream raw materials:

(1'S)-3,4-Dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzaldehyde

2-Ethoxy-5-methyl-3-((S)-1,2,2-trimethyl-cyclopentyl)-phenol

1-Benzyloxy-2-ethoxy-5-methyl-3-((S)-1,2,2-trimethyl-cyclopentyl)-benzene

1-Benzyloxy-2-isopropoxy-5-methyl-3-((S)-1,2,2-trimethyl-cyclopentyl)-benzene