C-[4-(4-CHLORO-BENZYL)-MORPHOLIN-2-YL]-METHYLAMINE DIHYDROCHLORIDE

Base Information

• Chemical Name: C-[4-(4-CHLORO-BENZYL)-MORPHOLIN-2-YL]-METHYLAMINE DIHYDROCHLORIDE
• CAS No.: 174560-80-6
• Molecular Formula: C12H17 Cl N2 O
• Molecular Weight: 240.733
• Hs Code.: 2934999090
• Mol file: 174560-80-6.mol

Synonyms:C-[4-(4-CHLORO-BENZYL)-MORPHOLIN-2-YL]-METHYLAMINE DIHYDROCHLORIDE

Chemical Property of C-[4-(4-CHLORO-BENZYL)-MORPHOLIN-2-YL]-METHYLAMINE DIHYDROCHLORIDE

Chemical Property:

• PSA: 38.49000
• LogP: 2.13770

Purity/Quality:

C-[4-(4-CHLORO-BENZYL)-MORPHOLIN-2-YL]-METHYLAMINE DIHYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of C-[4-(4-CHLORO-BENZYL)-MORPHOLIN-2-YL]-METHYLAMINE DIHYDROCHLORIDE

There total 5 articles about C-[4-(4-CHLORO-BENZYL)-MORPHOLIN-2-YL]-METHYLAMINE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-Chloro-4-(chloromethyl)benzene (104-83-6) + ethanolamine (141-43-5) → 2-aminomethyl-4-(p-chlorobenzyl)morpholine (174560-80-6)

Guidance literature:

With sodium hydroxide; In methanol;

Reference yield: 71.0%

4-(p-chlorobenzyl)-2-phthalimidomethylmorpholine (174560-82-8) → 2-aminomethyl-4-(p-chlorobenzyl)morpholine (174560-80-6)

Guidance literature:

With hydrazine hydrate; In 1,4-dioxane; ethanol; chloroform;

Reference yield:

2-(N-acetylaminomethyl)-4-benzylmorpholine (112913-96-9) → 2-aminomethyl-4-(p-chlorobenzyl)morpholine (174560-80-6)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂, AcOH / 10percent Pd/C / ethanol / 60 °C

2: K₂CO₃, KI / butan-2-one / 17 h / Heating

3: 10percent HCl / 4 h / Heating

With hydrogenchloride; hydrogen; potassium carbonate; acetic acid; potassium iodide; palladium on activated charcoal; In ethanol; butanone;

DOI:10.1021/jm00106a023

upstream raw materials:

N-[4-(4-Chloro-benzyl)-morpholin-2-ylmethyl]-acetamide

2-(N-acetylaminomethyl)-4-benzylmorpholine

<2-(acetylamino)methyl>morpholine acetyl salt

1-Chloro-4-(chloromethyl)benzene

Refernces

• 1、 Kato,Morie,Kon,Yoshida,Karasawa,Matsumoto. "Novel benzamides as selective and potent gastrokinetic agents. 2.1 Synthesis and structure-activity relationships of 4-amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2-morpholinyl]methyl] benzamide citrate (AS-4370) and related compounds". . p. 616 - 624. Retrieved 2007/10/02.