3'-Thymidylicacid,N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-P-(2-chlorophenyl)-2'-deoxyadenylyl-(3'®5')-, 2-chlorophenyl 2-cyanoethyl ester (9CI)

Base Information

Chemical Name:3'-Thymidylicacid,N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-P-(2-chlorophenyl)-2'-deoxyadenylyl-(3'®5')-, 2-chlorophenyl 2-cyanoethyl ester (9CI)
CAS No.:78098-91-6
Molecular Formula:C63H58 Cl2 N8 O16 P2
Molecular Weight:1316.05
Hs Code.:

3'-Thymidylicacid,N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-P-(2-chlorophenyl)-2'-deoxyadenylyl-(3'®5')-, 2-chlorophenyl 2-cyanoethyl ester (9CI)

Synonyms:

Suppliers and Price of 3'-Thymidylicacid,N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-P-(2-chlorophenyl)-2'-deoxyadenylyl-(3'®5')-, 2-chlorophenyl 2-cyanoethyl ester (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 5 raw suppliers

Chemical Property of 3'-Thymidylicacid,N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-P-(2-chlorophenyl)-2'-deoxyadenylyl-(3'®5')-, 2-chlorophenyl 2-cyanoethyl ester (9CI)

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3'-Thymidylicacid,N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-P-(2-chlorophenyl)-2'-deoxyadenylyl-(3'®5')-, 2-chlorophenyl 2-cyanoethyl ester (9CI)

There total 15 articles about 3'-Thymidylicacid,N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-P-(2-chlorophenyl)-2'-deoxyadenylyl-(3'®5')-, 2-chlorophenyl 2-cyanoethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 78272-53-4
Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

: 80817-40-9
2'-deoxythymidine-3'-O-(2-chlorophenyl-2-cyanoethyl)phosphate

: 78098-91-6
C₆₃H₅₈Cl₂N₈O₁₆P₂

Guidance literature:: With 1-(2,4,6-triisopropylbenzenesulfonyl)-3-nitro-1,2,4-triazole; In pyridine; at 20 ℃; for 3.5h;
DOI:10.1002/hlca.19820650803

Reference yield:

: 72351-28-1
2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide)

: 78098-91-6
C₆₃H₅₈Cl₂N₈O₁₆P₂

Guidance literature:: Multi-step reaction with 4 steps

1: dioxane / 2 h / 20 °C

2: 1-methylimidazole / dioxane / 3 h / 20 °C

3: benzenesulfonic acid / CHCl₃; methanol / 0.25 h / 0 °C

4: 62 percent / 1-(2,4,6-triisopropylbenzenesulfonyl)-3-nitro-1,2,4-triazole / pyridine / 3.5 h / 20 °C

With 1-(2,4,6-triisopropylbenzenesulfonyl)-3-nitro-1,2,4-triazole; benzenesulfonic acid; 1-methyl-1H-imidazole; In 1,4-dioxane; pyridine; methanol; chloroform;
DOI:10.1002/hlca.19820650803

Reference yield:

: 76958-58-2
[1,2,4]Triazol-1-yl-phosphonic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

: 78098-91-6
C₆₃H₅₈Cl₂N₈O₁₆P₂

Guidance literature:: Multi-step reaction with 3 steps

1: 1-methylimidazole / dioxane / 3 h / 20 °C

2: benzenesulfonic acid / CHCl₃; methanol / 0.25 h / 0 °C

3: 62 percent / 1-(2,4,6-triisopropylbenzenesulfonyl)-3-nitro-1,2,4-triazole / pyridine / 3.5 h / 20 °C

With 1-(2,4,6-triisopropylbenzenesulfonyl)-3-nitro-1,2,4-triazole; benzenesulfonic acid; 1-methyl-1H-imidazole; In 1,4-dioxane; pyridine; methanol; chloroform;
DOI:10.1002/hlca.19820650803