(2R,3S,αR)-1-(pyrrolidin-1'-yl)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)-2-methylbutan-1-one

Base Information

Chemical Name:(2R,3S,αR)-1-(pyrrolidin-1'-yl)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)-2-methylbutan-1-one
CAS No.:944410-94-0
Molecular Formula:C₃₀H₄₆N₂O₂Si
Molecular Weight:494.793
Hs Code.:

Synonyms:(2R,3S,αR)-1-(pyrrolidin-1'-yl)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)-2-methylbutan-1-one

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Chemical Property of (2R,3S,αR)-1-(pyrrolidin-1'-yl)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)-2-methylbutan-1-one

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Technology Process of (2R,3S,αR)-1-(pyrrolidin-1'-yl)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)-2-methylbutan-1-one

There total 6 articles about (2R,3S,αR)-1-(pyrrolidin-1'-yl)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)-2-methylbutan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 944410-78-0
(3S,αR)-1-(pyrrolidin-1'-yl)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)butan-1-one

: 74-88-4
methyl iodide

: 944410-94-0
(2R,3S,αR)-1-(pyrrolidin-1'-yl)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)-2-methylbutan-1-one

: 944410-93-9
(2S,3S,αR)-1-(pyrrolidin-1'-yl)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)-2-methylbutan-1-one

Guidance literature:: (3S,αR)-1-(pyrrolidin-1'-yl)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)butan-1-one; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 2h;

methyl iodide; In tetrahydrofuran; at -78 - 20 ℃; Further stages.;
DOI:10.1016/j.tet.2007.03.026

Reference yield:

: 944410-74-6
(Z)-1-(pyrrolidin-1'-yl)-4-(tert-butyldimethylsilyloxy)but-2-en-1-one

: 944410-94-0
(2R,3S,αR)-1-(pyrrolidin-1'-yl)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)-2-methylbutan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 60 percent / diphenyl disulfide / hexane / 4 h / 25 °C / Photolysis

2.1: 54 percent / hexane; tetrahydrofuran / 2 h / -78 °C

3.1: lithium diisopropylamide / tetrahydrofuran / 2 h / -78 °C

3.2: tetrahydrofuran / -78 - 20 °C

With diphenyldisulfane; lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1016/j.tet.2007.03.026

Reference yield:

: 944410-70-2
(1S,2S,3S,4R)-{3-(hydroxymethyl)-7-oxabicyclo[2.2.1]hept-5-en-2-yl}(pyrrolidin-1'-yl)methanone

: 944410-94-0
(2R,3S,αR)-1-(pyrrolidin-1'-yl)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)-2-methylbutan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: Et₃N / CH₂Cl₂ / 48 h / 20 °C

2.1: 81 percent / 0.08 h / Pyrolysis

3.1: 60 percent / diphenyl disulfide / hexane / 4 h / 25 °C / Photolysis

4.1: 54 percent / hexane; tetrahydrofuran / 2 h / -78 °C

5.1: lithium diisopropylamide / tetrahydrofuran / 2 h / -78 °C

5.2: tetrahydrofuran / -78 - 20 °C

With triethylamine; diphenyldisulfane; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.tet.2007.03.026