methyl 2-{[N-(2-bromoallyl)-4-methylphenylsulfonamido](phenyl)methyl}acrylate

Base Information

• Chemical Name: methyl 2-{[N-(2-bromoallyl)-4-methylphenylsulfonamido](phenyl)methyl}acrylate
• CAS No.: 1018071-76-5
• Molecular Formula: C₂₁H₂₂BrNO₄S
• Molecular Weight: 464.38
• Mol file: 1018071-76-5.mol

Synonyms:methyl 2-{[N-(2-bromoallyl)-4-methylphenylsulfonamido](phenyl)methyl}acrylate

Chemical Property of methyl 2-{[N-(2-bromoallyl)-4-methylphenylsulfonamido](phenyl)methyl}acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-{[N-(2-bromoallyl)-4-methylphenylsulfonamido](phenyl)methyl}acrylate

There total 1 articles about methyl 2-{[N-(2-bromoallyl)-4-methylphenylsulfonamido](phenyl)methyl}acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Methyl 3-acetoxy-2-methylene-3-phenylpropanoate (124957-36-4) + toluene-4-sulfonamide (70-55-3) + 2-bromoallyl bromide (513-31-5) → methyl 2-{[N-(2-bromoallyl)-4-methylphenylsulfonamido](phenyl)methyl}acrylate (1018071-76-5)

Guidance literature:

Methyl 3-acetoxy-2-methylene-3-phenylpropanoate; With 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; water; at 20 ℃;

toluene-4-sulfonamide; In tetrahydrofuran; water; at 20 ℃;

2-bromoallyl bromide; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 6h; Further stages.;

DOI:10.1016/j.tetlet.2007.12.133

Reference yield: 68.0%

methyl 2-{[N-(2-bromoallyl)-4-methylphenylsulfonamido](phenyl)methyl}acrylate (1018071-76-5) → 5-methylene-2-phenyl-1-tosyl-1,2,5,6-tetrahydropyridine-3-carboxylate (1018071-84-5)

Guidance literature:

With palladium diacetate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; at 80 - 90 ℃; for 3h; Inert atmosphere;

DOI:10.1002/adsc.201300211

upstream raw materials:

Methyl 3-acetoxy-2-methylene-3-phenylpropanoate

toluene-4-sulfonamide

2-bromoallyl bromide

Downstream raw materials:

5-methylene-2-phenyl-1-tosyl-1,2,5,6-tetrahydropyridine-3-carboxylate