2-(3-chloro-4-cyanophenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Base Information

Chemical Name:2-(3-chloro-4-cyanophenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide
CAS No.:1428790-19-5
Molecular Formula:C₂₁H₂₀ClF₃N₄O
Molecular Weight:436.864
Hs Code.:

Synonyms:2-(3-chloro-4-cyanophenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

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Chemical Property of 2-(3-chloro-4-cyanophenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

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Technology Process of 2-(3-chloro-4-cyanophenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

There total 6 articles about 2-(3-chloro-4-cyanophenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 935518-08-4
(2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methanamine

: 1402586-05-3
2-(3-chloro-4-cyanophenyl)propanoic acid

: 1428790-19-5
2-(3-chloro-4-cyanophenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In acetonitrile; at 23 ℃; for 15h;

Reference yield:

: 1402586-04-2
methyl 2-(3-chloro-4-cyanophenyl)propanoate

: 1428790-19-5
2-(3-chloro-4-cyanophenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / tetrahydrofuran; water / 15 h / 20 °C

1.2: pH 3 - 4

2.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol; (2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methanamine / acetonitrile / 15 h / 20 °C

With (2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methanamine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; sodium hydroxide; In tetrahydrofuran; water; acetonitrile;

Reference yield:

: 33697-81-3
(3-chloro-4-hydroxy-phenyl)-acetic acid

: 1428790-19-5
2-(3-chloro-4-cyanophenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / 15 h / Reflux

2.1: trimethylamine / dichloromethane / 2 h / 0 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 34 h / 80 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

5.1: sodium hydroxide / tetrahydrofuran; water / 15 h / 20 °C

5.2: pH 3 - 4

6.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol; (2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methanamine / acetonitrile / 15 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; (2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methanamine; sulfuric acid; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; sodium hydroxide; trimethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;