tert-butyl 2-chloro-4-(1-oxo-1-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate

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Chemical Name:tert-butyl 2-chloro-4-(1-oxo-1-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate
CAS No.:1428790-20-8
Molecular Formula:C₂₆H₃₂ClF₃N₄O₃
Molecular Weight:541.013
Hs Code.:

Synonyms:tert-butyl 2-chloro-4-(1-oxo-1-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate

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Chemical Property of tert-butyl 2-chloro-4-(1-oxo-1-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate

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Technology Process of tert-butyl 2-chloro-4-(1-oxo-1-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate

There total 8 articles about tert-butyl 2-chloro-4-(1-oxo-1-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1428790-19-5
2-(3-chloro-4-cyanophenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

: 1428790-20-8
tert-butyl 2-chloro-4-(1-oxo-1-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate

Guidance literature:: di-tert-butyl dicarbonate; 2-(3-chloro-4-cyanophenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide; With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate; at 0 - 23 ℃; for 2h;

With 3-azapentane-1,5-diamine; for 1h;

Reference yield:

: 33697-81-3
(3-chloro-4-hydroxy-phenyl)-acetic acid

: 1428790-20-8
tert-butyl 2-chloro-4-(1-oxo-1-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / 15 h / Reflux

2.1: trimethylamine / dichloromethane / 2 h / 0 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 34 h / 80 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

5.1: sodium hydroxide / tetrahydrofuran; water / 15 h / 20 °C

5.2: pH 3 - 4

6.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol; (2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methanamine / acetonitrile / 15 h / 20 °C

7.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 1 h / 0 - 20 °C

7.2: 1 h

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; (2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methanamine; nickel(II) chloride hexahydrate; sulfuric acid; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; sodium hydroxide; trimethylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 496856-45-2
(3-chloro-4-cyanophenyl)acetic acid methyl ester

: 1428790-20-8
tert-butyl 2-chloro-4-(1-oxo-1-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)propan-2-yl)benzylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

2.1: sodium hydroxide / tetrahydrofuran; water / 15 h / 20 °C

2.2: pH 3 - 4

3.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol; (2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methanamine / acetonitrile / 15 h / 20 °C

4.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol / 1 h / 0 - 20 °C

4.2: 1 h

With sodium tetrahydroborate; (2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methanamine; nickel(II) chloride hexahydrate; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; sodium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;