2-(4-Amino-3-phenyl-pyrazolo[3,4-d]pyrimidin-1-yl)-propane-1,3-diol

Base Information

• Chemical Name: 2-(4-Amino-3-phenyl-pyrazolo[3,4-d]pyrimidin-1-yl)-propane-1,3-diol
• CAS No.: 131192-73-9
• Molecular Formula: C₁₄H₁₅N₅O₂
• Molecular Weight: 285.305
• Mol file: 131192-73-9.mol

Synonyms:2-(4-Amino-3-phenyl-pyrazolo[3,4-d]pyrimidin-1-yl)-propane-1,3-diol

Chemical Property of 2-(4-Amino-3-phenyl-pyrazolo[3,4-d]pyrimidin-1-yl)-propane-1,3-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-Amino-3-phenyl-pyrazolo[3,4-d]pyrimidin-1-yl)-propane-1,3-diol

There total 5 articles about 2-(4-Amino-3-phenyl-pyrazolo[3,4-d]pyrimidin-1-yl)-propane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

Acetic acid 3-acetoxy-2-(4-amino-3-phenyl-pyrazolo[3,4-d]pyrimidin-1-yl)-propyl ester (130867-99-1) → 2-(4-Amino-3-phenyl-pyrazolo[3,4-d]pyrimidin-1-yl)-propane-1,3-diol (131192-73-9)

Guidance literature:

With ammonia; In ethanol; for 20h; Ambient temperature;

DOI:10.1016/0223-5234(90)90005-N

Reference yield:

5-Amino-1-(2-benzyloxy-1-benzyloxymethyl-ethyl)-3-phenyl-1H-pyrazole-4-carbonitrile (130867-80-0) → 2-(4-Amino-3-phenyl-pyrazolo[3,4-d]pyrimidin-1-yl)-propane-1,3-diol (131192-73-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 2.) NH₃ / 1.) reflux, 8 h, 2.) ethanol, RT

2: 62 percent / boron trifluoride etherate / Ambient temperature

3: 68 percent / NH₃ / ethanol / 20 h / Ambient temperature

With boron trifluoride diethyl etherate; ammonia; In ethanol;

DOI:10.1016/0223-5234(90)90005-N

Reference yield:

1-(2-Benzyloxy-1-benzyloxymethyl-ethyl)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine (130867-55-9) → 2-(4-Amino-3-phenyl-pyrazolo[3,4-d]pyrimidin-1-yl)-propane-1,3-diol (131192-73-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / boron trifluoride etherate / Ambient temperature

2: 68 percent / NH₃ / ethanol / 20 h / Ambient temperature

With boron trifluoride diethyl etherate; ammonia; In ethanol;

DOI:10.1016/0223-5234(90)90005-N

upstream raw materials:

Acetic acid 3-acetoxy-2-(4-amino-3-phenyl-pyrazolo[3,4-d]pyrimidin-1-yl)-propyl ester

5-Amino-1-(2-benzyloxy-1-benzyloxymethyl-ethyl)-3-phenyl-1H-pyrazole-4-carbonitrile

1-(2-Benzyloxy-1-benzyloxymethyl-ethyl)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine

5-amino-3-phenyl-1H-pyrazole-4-carbonitrile