3-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]-1-[(1,1,3,3-tetramethylbutyl)amino]carbonylpropyl (2S)-2-[(tert-butoxycarbonyl)cyclohexyl]propanoate

Base Information

Chemical Name:3-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]-1-[(1,1,3,3-tetramethylbutyl)amino]carbonylpropyl (2S)-2-[(tert-butoxycarbonyl)cyclohexyl]propanoate
CAS No.:1309974-53-5
Molecular Formula:C₃₈H₆₃N₃O₈
Molecular Weight:689.934
Hs Code.:

3-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]-1-[(1,1,3,3-tetramethylbutyl)amino]carbonylpropyl (2S)-2-[(tert-butoxycarbonyl)cyclohexyl]propanoate

Synonyms:3-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]-1-[(1,1,3,3-tetramethylbutyl)amino]carbonylpropyl (2S)-2-[(tert-butoxycarbonyl)cyclohexyl]propanoate

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Chemical Property of 3-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]-1-[(1,1,3,3-tetramethylbutyl)amino]carbonylpropyl (2S)-2-[(tert-butoxycarbonyl)cyclohexyl]propanoate

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Technology Process of 3-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]-1-[(1,1,3,3-tetramethylbutyl)amino]carbonylpropyl (2S)-2-[(tert-butoxycarbonyl)cyclohexyl]propanoate

There total 5 articles about 3-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]-1-[(1,1,3,3-tetramethylbutyl)amino]carbonylpropyl (2S)-2-[(tert-butoxycarbonyl)cyclohexyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 14542-93-9
1,1,3,3-tetramethylbutane isonitrile

: 37736-82-6
(S)-2-tert-butoxycarbonylamino-3-cyclohexylpropionic acid

: 79069-54-8
(S)-2-(t-butoxycarbonylamino)-3-phenylmetoxy-1-propanal

: 1309974-53-5
3-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]-1-[(1,1,3,3-tetramethylbutyl)amino]carbonylpropyl (2S)-2-[(tert-butoxycarbonyl)cyclohexyl]propanoate

Guidance literature:: In dichloromethane; at 20 ℃; for 48h;

Reference yield:

: 3262-72-4
(S)-N-(tert-butoxycarbonyl)serine

: 1309974-53-5
3-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]-1-[(1,1,3,3-tetramethylbutyl)amino]carbonylpropyl (2S)-2-[(tert-butoxycarbonyl)cyclohexyl]propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

1.2: 25 °C / Inert atmosphere

2.1: 4-methyl-morpholine; isobutyl chloroformate / 1,2-dimethoxyethane / -20 °C

2.2: 0.5 h / Cooling with ice

3.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

4.1: dichloromethane / 48 h / 20 °C

With 4-methyl-morpholine; sodium hydride; Dess-Martin periodane; isobutyl chloroformate; In 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; 4.1: Passerini Reaction;

Reference yield:

: 100-39-0
benzyl bromide

: 1309974-53-5
3-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]-1-[(1,1,3,3-tetramethylbutyl)amino]carbonylpropyl (2S)-2-[(tert-butoxycarbonyl)cyclohexyl]propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

1.2: 25 °C / Inert atmosphere

2.1: 4-methyl-morpholine; isobutyl chloroformate / 1,2-dimethoxyethane / -20 °C

2.2: 0.5 h / Cooling with ice

3.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

4.1: dichloromethane / 48 h / 20 °C

With 4-methyl-morpholine; sodium hydride; Dess-Martin periodane; isobutyl chloroformate; In 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; 4.1: Passerini Reaction;