C₁₂H₁₂ClNO₆

Base Information

• Chemical Name: C₁₂H₁₂ClNO₆
• CAS No.: 748789-30-2
• Molecular Formula: C₁₂H₁₂ClNO₆
• Molecular Weight: 301.683
• Mol file: 748789-30-2.mol

Synonyms:C₁₂H₁₂ClNO₆

Chemical Property of C₁₂H₁₂ClNO₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₁₂ClNO₆

There total 3 articles about C₁₂H₁₂ClNO₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 4-(2-hydroxy-1-methylethyl)-3-nitrobenzoate (702643-06-9) + trichloromethyl chloroformate (503-38-8) → C12H12ClNO6 (748789-30-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1002/hlca.200490060

Reference yield:

4-ethyl-3-nitro-benzoic acid methyl ester (51885-79-1) → C12H12ClNO6 (748789-30-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 39 percent / tBuOK / dimethylsulfoxide; 2-methyl-propan-2-ol / 20 - 80 °C

2: 100 percent / Et₃N / tetrahydrofuran / 1 h / 0 °C

With potassium tert-butylate; triethylamine; In tetrahydrofuran; dimethyl sulfoxide; tert-butyl alcohol;

DOI:10.1002/hlca.200490060

Reference yield:

4-Ethyl-3-nitrobenzoic acid (103440-95-5) → C12H12ClNO6 (748789-30-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / H₂SO₄ / 3 h / Heating

2: 39 percent / tBuOK / dimethylsulfoxide; 2-methyl-propan-2-ol / 20 - 80 °C

3: 100 percent / Et₃N / tetrahydrofuran / 1 h / 0 °C

With sulfuric acid; potassium tert-butylate; triethylamine; In tetrahydrofuran; dimethyl sulfoxide; tert-butyl alcohol;

DOI:10.1002/hlca.200490060

upstream raw materials:

methyl 4-(2-hydroxy-1-methylethyl)-3-nitrobenzoate

trichloromethyl chloroformate

4-ethyl-3-nitro-benzoic acid methyl ester

4-Ethyl-3-nitrobenzoic acid