4-Ethyl-3-nitro-benzoic acid Methyl ester

Base Information

• Chemical Name: 4-Ethyl-3-nitro-benzoic acid Methyl ester
• CAS No.: 51885-79-1
• Molecular Formula: C10H11NO4
• Molecular Weight: 209.202
• Mol file: 51885-79-1.mol

Synonyms:4-Ethyl-3-nitro-benzoic acid Methyl ester;Methyl 4-Ethyl-3-Nitrobenzoate;Benzoic acid, 4-ethyl-3-nitro-, methyl ester

Chemical Property of 4-Ethyl-3-nitro-benzoic acid Methyl ester

Chemical Property:

• Boiling Point: 314.6±30.0 °C(Predicted)
• PSA: 72.12000
• Density: 1.216±0.06 g/cm3(Predicted)
• LogP: 2.46700

Purity/Quality:

99% ^*data from raw suppliers

4-Ethyl-3-nitro-benzoicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Ethyl-3-nitro-benzoic acid Methyl ester

There total 7 articles about 4-Ethyl-3-nitro-benzoic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + 4-Ethyl-3-nitrobenzoic acid (103440-95-5) → 4-ethyl-3-nitro-benzoic acid methyl ester (51885-79-1)

Guidance literature:

With thionyl chloride; at 0 - 50 ℃; for 4h;

Reference yield:

p-ethylbenzoic acid (619-64-7) → 4-ethyl-3-nitro-benzoic acid methyl ester (51885-79-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; nitric acid / 2 h / 0 °C

2: hydrogenchloride / 20 h / Reflux

With hydrogenchloride; sulfuric acid; nitric acid;

Reference yield:

4-ethyl-3-nitro-benzaldehyde (4748-80-5) → 4-ethyl-3-nitro-benzoic acid methyl ester (51885-79-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium permanganate; sodium hydroxide / water / 2.5 h / Reflux

2.1: acetyl chloride / 0.17 h / 20 °C

2.2: 6 h / Reflux

With potassium permanganate; acetyl chloride; sodium hydroxide; In water;

upstream raw materials:

methanol

4-Ethyl-3-nitrobenzoic acid

4-ethyl-3-nitro-benzaldehyde

p-ethylbenzoic acid

Downstream raw materials:

C₁₇H₁₈N₄O₂

6-(methoxycarbonyl)-3-methyl-1H-indazole

4-(1-bromoethyl)-3-nitrobenzoic acid methyl ester

methyl 4-(1-methoxyethyl)-3-nitrobenzoate

Refernces

• 1、 -. "HISTONE DEMETHYLASE INHIBITORS". Paragraph 00687; 00688. . Retrieved 2014/06/24.
• 2、 Lee, Ju Hun,Domaille, Dylan W.,Noh, Hyunwoo,Oh, Taeseok,Choi, Chulmin,Jin, Sungho,Cha, Jennifer N.. "High-yielding and photolabile approaches to the covalent attachment of biomolecules to surfaces via hydrazone chemistry". . p. 8452 - 8460. Retrieved 2014/08/05.