(3-(3-(2-fluorophenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)(morpholino)methanone

Base Information

Chemical Name:(3-(3-(2-fluorophenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)(morpholino)methanone
CAS No.:875639-36-4
Molecular Formula:C₃₁H₂₆FN₃O₄S
Molecular Weight:555.63
Hs Code.:

Synonyms:(3-(3-(2-fluorophenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)(morpholino)methanone

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Chemical Property of (3-(3-(2-fluorophenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)(morpholino)methanone

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Technology Process of (3-(3-(2-fluorophenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)(morpholino)methanone

There total 6 articles about (3-(3-(2-fluorophenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)(morpholino)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 875639-35-3
(3-(3-iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)-(morpholino)methanone

: 1993-03-9
o-fluorophenylboronic acid

: 875639-36-4
(3-(3-(2-fluorophenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)(morpholino)methanone

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; acetonitrile; at 90 ℃; for 0.5h;

Reference yield:

: 723281-55-8
[3-(morpholin-4-ylcarbonyl)phenyl]boronic acid

: 875639-36-4
(3-(3-(2-fluorophenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)(morpholino)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 15 h / 100 °C

2: N-iodo-succinimide / acetone / 0.33 h / 20 °C

3: potassium hydroxide; tetra(n-butyl)ammonium hydroxide / water; toluene / 15 h / 20 °C

4: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / acetonitrile / 0.5 h / 90 °C / Microwave irradiation

With potassium hydroxide; N-iodo-succinimide; tetra(n-butyl)ammonium hydroxide; sodium hydrogencarbonate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; acetone; toluene; acetonitrile;

Reference yield:

: 875639-33-1
(3-(1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)(morpholino)-methanone

: 875639-36-4
(3-(3-(2-fluorophenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)(morpholino)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: N-iodo-succinimide / acetone / 0.33 h / 20 °C

2: potassium hydroxide; tetra(n-butyl)ammonium hydroxide / water; toluene / 15 h / 20 °C

3: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / acetonitrile / 0.5 h / 90 °C / Microwave irradiation

With potassium hydroxide; N-iodo-succinimide; tetra(n-butyl)ammonium hydroxide; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; acetone; toluene; acetonitrile;