3-(2,6-dichloro-phenyl)-N⁷-(4-diethylamino-butyl)-[1,6]naphthyridine-2,7-diamine

Base Information

• Chemical Name: 3-(2,6-dichloro-phenyl)-N⁷-(4-diethylamino-butyl)-[1,6]naphthyridine-2,7-diamine
• CAS No.: 862370-06-7
• Molecular Formula: C₂₂H₂₇Cl₂N₅
• Molecular Weight: 432.396

Synonyms:3-(2,6-dichloro-phenyl)-N⁷-(4-diethylamino-butyl)-[1,6]naphthyridine-2,7-diamine

Chemical Property of 3-(2,6-dichloro-phenyl)-N⁷-(4-diethylamino-butyl)-[1,6]naphthyridine-2,7-diamine

Chemical Property:

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Technology Process of 3-(2,6-dichloro-phenyl)-N⁷-(4-diethylamino-butyl)-[1,6]naphthyridine-2,7-diamine

There total 2 articles about 3-(2,6-dichloro-phenyl)-N⁷-(4-diethylamino-butyl)-[1,6]naphthyridine-2,7-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

4-(diethylamino)butylamine (27431-62-5) + 3-(2,6-Dichlorophenyl)-7-fluoro-1,6-naphthyridin-2-amine (293301-19-6) → 3-(2,6-dichloro-phenyl)-N7-(4-diethylamino-butyl)-[1,6]naphthyridine-2,7-diamine (862370-06-7)

Guidance literature:

In 2-ethoxy-ethanol; for 120h; Heating;

DOI:10.1021/jm0500931

Reference yield:

N-(tert-butyl)-N'-[3-(2,6-dichlorophenyl)-7-fluoro-1,6-naphthyridin-2-yl]urea (862370-64-7) → 3-(2,6-dichloro-phenyl)-N7-(4-diethylamino-butyl)-[1,6]naphthyridine-2,7-diamine (862370-06-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 9 percent / various solvent(s) / 2 h / 120 °C

2: 36 percent / 2-ethoxy-ethanol / 120 h / Heating

In 2-ethoxy-ethanol;

DOI:10.1021/jm0500931

Reference yield: 59.0%

3-(2,6-dichloro-phenyl)-N7-(4-diethylamino-butyl)-[1,6]naphthyridine-2,7-diamine (862370-06-7) + Tert-butyl isocyanate (1609-86-5) → 1-tert-butyl-3-[3-(2,6-dichloro-phenyl)-7-(4-diethylamino-butylamino)-[1,6]naphthyridin-2-yl]-urea

Guidance literature:

3-(2,6-dichloro-phenyl)-N⁷-(4-diethylamino-butyl)-[1,6]naphthyridine-2,7-diamine; With sodium hydride; In dimethyl sulfoxide; for 0.666667h;

Tert-butyl isocyanate; In dimethyl sulfoxide; at 20 ℃; for 17h;

DOI:10.1021/jm0500931

upstream raw materials:

4-(diethylamino)butylamine

3-(2,6-Dichlorophenyl)-7-fluoro-1,6-naphthyridin-2-amine

N-(tert-butyl)-N'-[3-(2,6-dichlorophenyl)-7-fluoro-1,6-naphthyridin-2-yl]urea

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