Technology Process of (3-bromo-4-iodo-phenylethynyl)-trimethyl-silane
There total 3 articles about (3-bromo-4-iodo-phenylethynyl)-trimethyl-silane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-bromo-4-trimethylsilanylethynylaniline;
With
boron trifluoride diethyl etherate;
In
diethyl ether;
at -40 ℃;
for 0.416667h;
With
tert.-butylnitrite;
In
diethyl ether;
at -15 ℃;
for 0.333333h;
With
sodium iodide;
In
acetonitrile;
at 20 ℃;
DOI:10.1021/ja058514r
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 1.11 g / PdCl2(PPh3)2; CuI; NEt3 / 20 °C
2.1: BF3*OEt2 / diethyl ether / 0.42 h / -40 °C
2.2: t-BuONO / diethyl ether / 0.33 h / -15 °C
2.3: 0.92 g / NaI / acetonitrile / 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; boron trifluoride diethyl etherate; triethylamine;
In
diethyl ether;
1.1: Sonogashira reaction;
DOI:10.1021/ja058514r
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 1.34 g / NaHCO3; benzyltriethylammonium dichloroiodate / CH2Cl2; methanol / 0.33 h / 20 °C
2.1: 1.11 g / PdCl2(PPh3)2; CuI; NEt3 / 20 °C
3.1: BF3*OEt2 / diethyl ether / 0.42 h / -40 °C
3.2: t-BuONO / diethyl ether / 0.33 h / -15 °C
3.3: 0.92 g / NaI / acetonitrile / 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; boron trifluoride diethyl etherate; sodium hydrogencarbonate; N,N,N-trimethylbenzenemethanaminium dichloroiodate; triethylamine;
In
methanol; diethyl ether; dichloromethane;
2.1: Sonogashira reaction;
DOI:10.1021/ja058514r
