ethyl (2S)-2-{[6-fluoro-1-(4-methylphenyl)-1H-benzimidazol-2-yl]amino}propanoate

Base Information

Chemical Name:ethyl (2S)-2-{[6-fluoro-1-(4-methylphenyl)-1H-benzimidazol-2-yl]amino}propanoate
CAS No.:1613081-91-6
Molecular Formula:C₁₉H₂₀FN₃O₂
Molecular Weight:341.385
Hs Code.:

Synonyms:ethyl (2S)-2-{[6-fluoro-1-(4-methylphenyl)-1H-benzimidazol-2-yl]amino}propanoate

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Chemical Property of ethyl (2S)-2-{[6-fluoro-1-(4-methylphenyl)-1H-benzimidazol-2-yl]amino}propanoate

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Technology Process of ethyl (2S)-2-{[6-fluoro-1-(4-methylphenyl)-1H-benzimidazol-2-yl]amino}propanoate

There total 3 articles about ethyl (2S)-2-{[6-fluoro-1-(4-methylphenyl)-1H-benzimidazol-2-yl]amino}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1447934-60-2
5-fluoro-N-(4-methylphenyl)-2-nitrosoaniline

: 68778-13-2
ethyl (2S)-2-isocyanopropanoate

: 1613081-91-6
ethyl (2S)-2-{[6-fluoro-1-(4-methylphenyl)-1H-benzimidazol-2-yl]amino}propanoate

Guidance literature:: 5-fluoro-N-(4-methylphenyl)-2-nitrosoaniline; ethyl (2S)-2-isocyanopropanoate; With boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 3h;

With acetic acid; zinc; at 50 ℃; for 24h;
DOI:10.1016/j.tetlet.2014.04.030

Reference yield:

: 106-49-0,12221-03-3
p-toluidine

: 1613081-91-6
ethyl (2S)-2-{[6-fluoro-1-(4-methylphenyl)-1H-benzimidazol-2-yl]amino}propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.67 h / -78 °C

2.1: boron trifluoride diethyl etherate / dichloromethane / 3 h / 20 °C

2.2: 24 h / 50 °C

With boron trifluoride diethyl etherate; potassium tert-butylate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetlet.2014.04.030

Reference yield:

: 352-15-8
4-fluoro-nitrosobenzene

: 1613081-91-6
ethyl (2S)-2-{[6-fluoro-1-(4-methylphenyl)-1H-benzimidazol-2-yl]amino}propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.67 h / -78 °C

2.1: boron trifluoride diethyl etherate / dichloromethane / 3 h / 20 °C

2.2: 24 h / 50 °C

With boron trifluoride diethyl etherate; potassium tert-butylate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetlet.2014.04.030