352-15-8

Usage

Uses

Used in Chemical Synthesis:
4-Nitrofluorobenzol is utilized as a precursor in the synthesis of various chemicals and pharmaceuticals, contributing to the creation of a wide range of products due to its reactive functional groups.
Used in Organic Reactions:
As a reagent, 4-Nitrofluorobenzol is employed in organic reactions to facilitate specific chemical transformations, playing a crucial role in the advancement of organic chemistry and the development of new compounds.
Used in Pharmaceutical Industry:
4-Nitrofluorobenzol is used as a building block in the pharmaceutical industry for the development of new drugs, leveraging its chemical properties to create molecules with potential therapeutic applications.

Upstream product

• 350-46-9 4-Fluoronitrobenzene 
• 371-40-4 4-fluoroaniline 
• 455-17-4 (p-fluorophenyl)trimethylsilane 
• 1765-93-1 4-fluoroboronic acid 

Downstream Products

• 2802-96-2 N,O-bis-(1-cyano-1-methyl-ethyl)-N-(4-fluoro-phenyl)-hydroxylamine 
• 332-00-3 (E)-1-(4-fluorophenyl)-2-phenyldiazene 
• 326-04-5 1,2-bis(4-fluorophenyl)diazene oxide 
• 94664-77-4 (Z)-N-(4-fluorophenyl)-1-phenylmethanimine oxide 
• 39769-33-0 (4-Chloro-phenyl)-(4-fluoro-phenyl)-diazene 
• 118719-06-5 2-<4-(4'-fluorophenylazo)phenyl>propan-2-ol 
• 96018-74-5 4-fluoro-N-hydroxy-benzamide 
• 51788-97-7 (4-Fluoro-phenyl)-(4-trifluoromethyl-phenyl)-diazene 
• 332-07-0 (E)-bis(4-fluorophenyl)diazene 
• 51788-96-6 (E)-(4-fluorophenyl)-(4-iodophenyl)diazene 
• 39873-46-6 C₁₃H₁₁FN₂S 
• 1292800-94-2 C₁₂H₁₄FNO₂ 
• 326-04-5 N,N'-Bis-(4-fluoro-phenyl)-diazene N-oxide 

Relevant academic research and scientific papers

Solution Dynamics of Redox Noninnocent Nitrosoarene Ligands: Mapping the Electronic Criteria for the Formation of Persistent Metal-Coordinated Nitroxide Radicals

(Graph Presented) The redox-noninnocence of metal-coordinated C-organo nitrosoarenes has been established on the basis of solid-state characterization techniques, but the solution-phase properties of this class of metal-coordinated radicals have been rela

Synthesis of Nitrosobenzene Derivatives via Nitrosodesilylation Reaction

The electrophilic ipso-substitution of trimethylsilyl-substituted benzene derivatives into nitrosobenzene derivatives is reported. The optimization of the reaction conditions was performed for moderately electron-deficient, electron-rich, and sterically hindered starting materials by varying reaction time, temperature, and equivalents of NOBF4. Also, a stable intermediate of the nitrosation reaction could be characterized by 19F NMR which can be assigned to a NO+ adduct with the nitrosobenzene derivative. This complex decomposes upon aqueous workup and liberates the desired nitrosobenzene derivative.

Ipso-Nitrosation of arylboronic acids with chlorotrimethylsilane and sodium nitrite

Nitroso compounds are versatile reagents in synthetic organic chemistry. Herein, we disclose a feasible protocol for the ipso-nitrosation of aryl boronic acids using chlorotrimethylsilane-sodium nitrite unison as nitrosation reagent system.

Nitrosobenzene cross-dimerization: Structural selectivity in solution and in solid state

Possibility of nitrosobenzenes to form dimeric molecular structures (azodioxides) is used as a model for intermolecular selectivity investigations in solution as well as in solid state. Cross-dimerization of different combinations of p- and m-substituted nitrosobenzene pairs was studied by variable temperature 1H NMR, solid-state NMR (CP MAS), IR, and ab initio calculations. It is evident that p-nitronitrosobenzene behaves nonselectively because it forms dimers with all the studied nitrosobenzene partners. In contrast, p-methoxynitrosobenzene in most cases does not form dimers. The evidence that ability to form dimers is different in solution than in the solid state can be explained by influence of molecular arrangements in the crystal lattice.

Structural investigations of C-nitrosobenzenes. Part 1. Solution state 1H NMR studies

Ambient and low temperature 1H NMR spectra of a wide range of 3- and 4-monosubstituted, and some di- and tri-substituted C-nitrosobenzenes have enabled -N=O substituent constants for the static and rotating ring molecules to be calculated. This has provided information on the shielding anisotropy of the N=O group which in turn leads to the firm identification of the monomeric and dimeric solution species. In all cases lowering the solution temperature enhances the relative populations of dimers to monomers, with the (Z)-azodioxy dimer being preferred over the (E)-form, irrespective of the nature of the solid state dimeric structure.

Azoxy compound

An azoxy compound represented by the following general formula STR1 wherein R1 denotes a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkoxy group, a lower alkoxy-lower alkoxy group or a group of the formula X1 --C C--CH