[1-(4-chloro-phenyl)-2-(2-chloro-phenyl)-5-(2H-tetrazol-5-ylmethyl)-1H-imidazol-4-yl]-[4-(2-fluoro-phenyl)-piperidin-1-yl]-methanone

Base Information

Chemical Name:[1-(4-chloro-phenyl)-2-(2-chloro-phenyl)-5-(2H-tetrazol-5-ylmethyl)-1H-imidazol-4-yl]-[4-(2-fluoro-phenyl)-piperidin-1-yl]-methanone
CAS No.:1202017-78-4
Molecular Formula:C₂₉H₂₄Cl₂FN₇O
Molecular Weight:576.46
Hs Code.:

Synonyms:[1-(4-chloro-phenyl)-2-(2-chloro-phenyl)-5-(2H-tetrazol-5-ylmethyl)-1H-imidazol-4-yl]-[4-(2-fluoro-phenyl)-piperidin-1-yl]-methanone

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Chemical Property of [1-(4-chloro-phenyl)-2-(2-chloro-phenyl)-5-(2H-tetrazol-5-ylmethyl)-1H-imidazol-4-yl]-[4-(2-fluoro-phenyl)-piperidin-1-yl]-methanone

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Technology Process of [1-(4-chloro-phenyl)-2-(2-chloro-phenyl)-5-(2H-tetrazol-5-ylmethyl)-1H-imidazol-4-yl]-[4-(2-fluoro-phenyl)-piperidin-1-yl]-methanone

There total 7 articles about [1-(4-chloro-phenyl)-2-(2-chloro-phenyl)-5-(2H-tetrazol-5-ylmethyl)-1H-imidazol-4-yl]-[4-(2-fluoro-phenyl)-piperidin-1-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1313600-44-0
{3-(4-chloro-phenyl)-2-(2-chloro-phenyl)-5-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-3H-imidazol-4-yl}-acetonitrile

: 1202017-78-4
[1-(4-chloro-phenyl)-2-(2-chloro-phenyl)-5-(2H-tetrazol-5-ylmethyl)-1H-imidazol-4-yl]-[4-(2-fluoro-phenyl)-piperidin-1-yl]-methanone

Guidance literature:: With trimethylsilylazide; di(n-butyl)tin oxide; In toluene; at 160 ℃; for 0.333333h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 2-(2-chloro-phenyl)-1-(4-chloro-phenyl)-5-methyl-1H-imidazole-4-carboxylic acid ethyl ester

: 1202017-78-4
[1-(4-chloro-phenyl)-2-(2-chloro-phenyl)-5-(2H-tetrazol-5-ylmethyl)-1H-imidazol-4-yl]-[4-(2-fluoro-phenyl)-piperidin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / Inert atmosphere; Reflux

2: water / ethanol / Reflux

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.75 h

4: trimethylsilylazide; di(n-butyl)tin oxide / toluene / 0.33 h / 160 °C / Inert atmosphere; Microwave irradiation

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); trimethylsilylazide; water; di(n-butyl)tin oxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrachloromethane; ethanol; dichloromethane; toluene;

Reference yield:

: 873-32-5
2-Chlorobenzonitrile

: 1202017-78-4
[1-(4-chloro-phenyl)-2-(2-chloro-phenyl)-5-(2H-tetrazol-5-ylmethyl)-1H-imidazol-4-yl]-[4-(2-fluoro-phenyl)-piperidin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 20 °C / Inert atmosphere

1.2: 20 °C

2.1: sodium hydrogencarbonate / isopropyl alcohol / 18 h / Reflux

2.2: 16 h / Reflux

2.3: 4 h / 50 °C

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / Reflux

3.2: Heating

4.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / Inert atmosphere; Reflux

5.1: water / ethanol / Reflux

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.75 h

7.1: trimethylsilylazide; di(n-butyl)tin oxide / toluene / 0.33 h / 160 °C / Inert atmosphere; Microwave irradiation

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); trimethylsilylazide; water; sodium hexamethyldisilazane; di(n-butyl)tin oxide; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1'-carbonyldiimidazole; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; isopropyl alcohol; toluene;