{3-(4-chloro-phenyl)-2-(2-chloro-phenyl)-5-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-3H-imidazol-4-yl}-acetonitrile

Base Information

Chemical Name:{3-(4-chloro-phenyl)-2-(2-chloro-phenyl)-5-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-3H-imidazol-4-yl}-acetonitrile
CAS No.:1313600-44-0
Molecular Formula:C₂₉H₂₃Cl₂FN₄O
Molecular Weight:533.432
Hs Code.:

Synonyms:{3-(4-chloro-phenyl)-2-(2-chloro-phenyl)-5-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-3H-imidazol-4-yl}-acetonitrile

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Chemical Property of {3-(4-chloro-phenyl)-2-(2-chloro-phenyl)-5-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-3H-imidazol-4-yl}-acetonitrile

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Technology Process of {3-(4-chloro-phenyl)-2-(2-chloro-phenyl)-5-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-3H-imidazol-4-yl}-acetonitrile

There total 6 articles about {3-(4-chloro-phenyl)-2-(2-chloro-phenyl)-5-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-3H-imidazol-4-yl}-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 691875-81-7
4-(2-fluoro-phenyl)piperidine hydrochloride

: 1202017-64-8
1-(4-chloro-phenyl)-2-(2-chloro-phenyl)-5-cyanomethyl-1H-imidazole-4-carboxylic acid

: 1313600-44-0
{3-(4-chloro-phenyl)-2-(2-chloro-phenyl)-5-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-3H-imidazol-4-yl}-acetonitrile

Guidance literature:: 1-(4-chloro-phenyl)-2-(2-chloro-phenyl)-5-cyanomethyl-1H-imidazole-4-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 0.75h;

4-(2-fluoro-phenyl)piperidine hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

: 2-(2-chloro-phenyl)-1-(4-chloro-phenyl)-5-methyl-1H-imidazole-4-carboxylic acid ethyl ester

: 1313600-44-0
{3-(4-chloro-phenyl)-2-(2-chloro-phenyl)-5-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-3H-imidazol-4-yl}-acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / Inert atmosphere; Reflux

2: water / ethanol / Reflux

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.75 h

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrachloromethane; ethanol; dichloromethane;

Reference yield:

: 873-32-5
2-Chlorobenzonitrile

: 1313600-44-0
{3-(4-chloro-phenyl)-2-(2-chloro-phenyl)-5-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-3H-imidazol-4-yl}-acetonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 20 °C / Inert atmosphere

1.2: 20 °C

2.1: sodium hydrogencarbonate / isopropyl alcohol / 18 h / Reflux

2.2: 16 h / Reflux

2.3: 4 h / 50 °C

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / Reflux

3.2: Heating

4.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / Inert atmosphere; Reflux

5.1: water / ethanol / Reflux

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.75 h

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); water; sodium hexamethyldisilazane; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1'-carbonyldiimidazole; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; isopropyl alcohol;