Chemical Property of Cyclophosphamide-d4
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Melting Point:41-450C
- Refractive Index:1.506
- Boiling Point:336.099°C at 760 mmHg
- Flash Point:157.068°C
- PSA:51.38000
- Density:1.355g/cm3
- LogP:2.21280
- Storage Temp.:-20°C Freezer
- Purity/Quality:
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95% *data from raw suppliers
Cyclophosphamide-d4 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
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Description
Cyclophosphamide-d4 contains four deuterium atoms. It is intended for use as an internal standard for the quantification of cyclophosphamide by GC- or LC-MS. Cyclophosphamide is a nitrogen mustard alkylating agent used in the treatment of cancers and autoimmune disorders. In cells with low levels of aldehyde dehydrogenase, cyclophosphamide acts as a prodrug and is metabolized to the active compound phosphoramide mustard, which crosslinks with DNA and causes cell death.
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Uses
Cyclophosphamide-d4 is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. Cyclophosphamide-d4 cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen.