4-Hydroxy-4-(1H-imidazol-4-yl)piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-Hydroxy-4-(1H-imidazol-4-yl)piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 173469-30-2
• Molecular Formula: C13H21 N3 O3
• Molecular Weight: 267.328
• Hs Code.: 2933990090
• Mol file: 173469-30-2.mol

Synonyms:1-Piperidinecarboxylicacid, 4-hydroxy-4-(1H-imidazol-4-yl)-, 1,1-dimethylethyl ester (9CI)

Chemical Property of 4-Hydroxy-4-(1H-imidazol-4-yl)piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

• Vapor Pressure: 5.26E-10mmHg at 25°C
• Refractive Index: 1.561
• Boiling Point: 479.5°Cat760mmHg
• Flash Point: 243.8°C
• PSA: 78.45000
• Density: 1.238g/cm³
• LogP: 1.56610

Purity/Quality:

99%min ^*data from raw suppliers

4-HYDROXY-4-(1H-IMIDAZOL-4-YL)PIPERIDINE-1-CARBOXYLIC ACID-TERT-BUTYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Hydroxy-4-(1H-imidazol-4-yl)piperidine-1-carboxylic acid tert-butyl ester

There total 1 articles about 4-Hydroxy-4-(1H-imidazol-4-yl)piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-1 H-imidazole (2302-25-2) + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 4-<4-(4-hydroxy-1-tert-butoxycarbonyl)piperidyl>-(1H)-imidazole (173469-30-2)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1.) THF, 1.5 h, 10-15 deg C, 2.) THF, room temperature;

DOI:10.1016/0040-4020(95)00881-8

Reference yield:

4-<4-(4-hydroxy-1-tert-butoxycarbonyl)piperidyl>-(1H)-imidazole (173469-30-2) → thioperamide (106243-16-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / concd. aq. HCl / 40 h / 95 °C

2: 88 percent / hydrogen / PtO₂ / acetic acid; H₂O / 24 h / 2585.7 Torr / Ambient temperature

3: 1.) NaOH / 1.) methanol, 30 min, 2.) acetonitrile, 2 h, 50 deg C; 40 h, room temperature

With hydrogenchloride; sodium hydroxide; hydrogen; platinum(IV) oxide; In water; acetic acid;

DOI:10.1016/0040-4020(95)00881-8

upstream raw materials:

4-bromo-1 H-imidazole

N-tert-butyloxycarbonylpiperidin-4-one

Downstream raw materials:

thioperamide

Refernces