106243-16-7 Usage
Uses
Thioperamide is a highly potent and selective ligand for histamine H3-receptors.
Biological Activity
Potent histamine H 3 and H 4 antagonist/inverse agonist. K i values are 25 and 27 nM for human recombinant H 3 and H 4 receptors respectively. Blocks eosinophil shape change (IC 50 = 1.4 μ M) and chemotaxis (IC 50 = 519 nM) induced by histamine. Freely crosses the blood-brain barrier. Also available as part of the Histamine H 3 Receptor Tocriset? .
Check Digit Verification of cas no
The CAS Registry Mumber 106243-16-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,2,4 and 3 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 106243-16:
(8*1)+(7*0)+(6*6)+(5*2)+(4*4)+(3*3)+(2*1)+(1*6)=87
87 % 10 = 7
So 106243-16-7 is a valid CAS Registry Number.
InChI:InChI=1/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)
106243-16-7Relevant articles and documents
Two Novel Syntheses of the Histamine H3 Antagonist Thioperamide
Lange, Jos H. M.,Wals, Henri C.,Hoogenband, Adri van den,Kuilen, Aalt van de,Hartog, Jack A. J. den
, p. 13447 - 13454 (2007/10/02)
The previously described route for the synthesis of the histamine H3 antagonist thioperamide 3 has been improved considerably.Furthermore, two straightforward novel synthetic routes towards 3 are described herein.The last synthetic route (Scheme 3) is preferable as it is very suitable for the production of multigram quantities of thioperamide 3.
