(S)-4-methyl-N-(2-methylbut-3-en-1-yl)-N-(prop-2-yn-1-yl)benzenesulfonamide

Base Information

• Chemical Name: (S)-4-methyl-N-(2-methylbut-3-en-1-yl)-N-(prop-2-yn-1-yl)benzenesulfonamide
• CAS No.: 1252666-85-5
• Molecular Formula: C₁₅H₁₉NO₂S
• Molecular Weight: 277.387
• Mol file: 1252666-85-5.mol

Synonyms:(S)-4-methyl-N-(2-methylbut-3-en-1-yl)-N-(prop-2-yn-1-yl)benzenesulfonamide

Chemical Property of (S)-4-methyl-N-(2-methylbut-3-en-1-yl)-N-(prop-2-yn-1-yl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of (S)-4-methyl-N-(2-methylbut-3-en-1-yl)-N-(prop-2-yn-1-yl)benzenesulfonamide

There total 1 articles about (S)-4-methyl-N-(2-methylbut-3-en-1-yl)-N-(prop-2-yn-1-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

methylmagnesium bromide (75-16-1) + (E)-N-(4-bromo-2-buten-1-yl)-4-methyl-N-(2-propyn-1-yl)-benzenesulfonamide (516518-05-1) → (S)-4-methyl-N-(2-methylbut-3-en-1-yl)-N-(prop-2-yn-1-yl)benzenesulfonamide (1252666-85-5)

Guidance literature:

With copper(I) bromide dimethylsulfide complex; (R,Rp)-1-(2-(diphenylphosphino)ferrocenyl)-1-(2-diphenylphosphinophenyl)-N,N-dimethylmethanamine; In diethyl ether; dichloromethane; at -80 ℃; for 16.8h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ol101944j

Reference yield: 77.0%

(S)-4-methyl-N-(2-methylbut-3-en-1-yl)-N-(prop-2-yn-1-yl)benzenesulfonamide (1252666-85-5) → (S)-3-methyl-1-tosyl-5-vinyl-1,2,3,6-tetrahydropyridine (1252666-88-8)

Guidance literature:

With Grubbs catalyst first generation; ethene; In dichloromethane; for 16h; under 760.051 Torr; Reflux;

DOI:10.1021/ol101944j

upstream raw materials:

methylmagnesium bromide

(E)-N-(4-bromo-2-buten-1-yl)-4-methyl-N-(2-propyn-1-yl)-benzenesulfonamide

Downstream raw materials:

(S)-3-methyl-1-tosyl-5-vinyl-1,2,3,6-tetrahydropyridine