(4S,6S)-1-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-oct-7-en-4-ol

Base Information

• Chemical Name: (4S,6S)-1-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-oct-7-en-4-ol
• CAS No.: 1028281-31-3
• Molecular Formula: C₂₅H₃₆O₂Si
• Molecular Weight: 396.645
• Mol file: 1028281-31-3.mol

Synonyms:(4S,6S)-1-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-oct-7-en-4-ol

Chemical Property of (4S,6S)-1-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-oct-7-en-4-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S,6S)-1-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-oct-7-en-4-ol

There total 3 articles about (4S,6S)-1-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-oct-7-en-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3S,5R)-5-[(S)-1-Bromo-3-(tert-butyl-diphenyl-silanyloxy)-propyl]-3-methyl-dihydro-furan-2-one → (4S,6S)-1-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-oct-7-en-4-ol (1028281-31-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / AIBN; NaBH₃CN / tributyltin hydride / benzene; 2-methyl-propan-2-ol / 84 °C

2: DIBAL / CH₂Cl₂ / -78 °C

3: n-BuLi / 0 °C

With n-butyllithium; 2,2'-azobis(isobutyronitrile); diisobutylaluminium hydride; sodium cyanoborohydride; tri-n-butyl-tin hydride; In dichloromethane; tert-butyl alcohol; benzene; 3: Wittig reaction;

DOI:10.1021/ol049292p

Reference yield:

(3S,5S)-5-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-3-methyl-dihydro-furan-2-one → (4S,6S)-1-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-oct-7-en-4-ol (1028281-31-3)

Guidance literature:

Multi-step reaction with 2 steps

1: DIBAL / CH₂Cl₂ / -78 °C

2: n-BuLi / 0 °C

With n-butyllithium; diisobutylaluminium hydride; In dichloromethane; 2: Wittig reaction;

DOI:10.1021/ol049292p

Reference yield:

Methyltriphenylphosphonium bromide (1779-49-3) + (2S,4S)-7-(tert-Butyl-diphenyl-silanyloxy)-4-hydroxy-2-methyl-heptanal → (4S,6S)-1-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-oct-7-en-4-ol (1028281-31-3)

Guidance literature:

With n-butyllithium; at 0 ℃;

DOI:10.1021/ol049292p

upstream raw materials:

Methyltriphenylphosphonium bromide

Downstream raw materials:

(S)-2-[((2R,4S)-2,4-Dimethyl-hex-5-enoyl)-methyl-amino]-3-phenyl-propionic acid (1R,3S)-1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-3-methyl-pent-4-enyl ester

(Z)-(3S,6R,8S,11S,13R)-3-Benzyl-13-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-4,6,8,11-tetramethyl-1-oxa-4-aza-cyclotridec-9-ene-2,5-dione

(3S,6R,8R,11R,13R)-3-Benzyl-13-(3-hydroxy-propyl)-4,6,8,11-tetramethyl-1-oxa-4-aza-cyclotridecane-2,5-dione

2-(tert-butoxycarbonyl-methyl-amino)-3-phenyl-propionic acid 1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-3-methyl-pent-4-enyl ester