(E)-1-(trifluoromethoxy)-4-(3,3,3-trifluoroprop-1-en-1-yl)benzene

Base Information

• Chemical Name: (E)-1-(trifluoromethoxy)-4-(3,3,3-trifluoroprop-1-en-1-yl)benzene
• CAS No.: 1425647-14-8
• Molecular Formula: C₁₀H₆F₆O
• Molecular Weight: 256.147
• Mol file: 1425647-14-8.mol

Synonyms:(E)-1-(trifluoromethoxy)-4-(3,3,3-trifluoroprop-1-en-1-yl)benzene

Chemical Property of (E)-1-(trifluoromethoxy)-4-(3,3,3-trifluoroprop-1-en-1-yl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-(trifluoromethoxy)-4-(3,3,3-trifluoroprop-1-en-1-yl)benzene

There total 4 articles about (E)-1-(trifluoromethoxy)-4-(3,3,3-trifluoroprop-1-en-1-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

Togni's reagent II (887144-94-7) + 4-trifluoromethoxycinnamic acid (783-13-1) → (E)-1-(trifluoromethoxy)-4-(3,3,3-trifluoroprop-1-en-1-yl)benzene (1425647-14-8)

Guidance literature:

With fac-tris(2-phenylpyridinato-N,C₂')iridium(III); sodium acetate; In dimethyl sulfoxide; at 20 ℃; Schlenk technique; Irradiation; Inert atmosphere;

DOI:10.1039/c3cc48598f

Reference yield:

Togni's reagent II (887144-94-7) + potassium (E)-(2-(4-trifluoromethoxyphenyl)ethenyl)trifluoroborate → (E)-1-(trifluoromethoxy)-4-(3,3,3-trifluoroprop-1-en-1-yl)benzene (1425647-14-8) + (Z)-1-(3,3,3-trifluoroprop-1-enyl)-4-trifluoromethoxybenzene (1425647-16-0)

Guidance literature:

With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; In methanol; at 20 ℃; for 5h; Overall yield = 69 %; Overall yield = 42 mg; stereoselective reaction; Inert atmosphere; Irradiation; Schlenk technique;

DOI:10.1039/c3cc39235j

Reference yield:

1-ethynyl-4-(trifluoromethoxy)benzene (160542-02-9) → (E)-1-(trifluoromethoxy)-4-(3,3,3-trifluoroprop-1-en-1-yl)benzene (1425647-14-8) + (Z)-1-(3,3,3-trifluoroprop-1-enyl)-4-trifluoromethoxybenzene (1425647-16-0)

Guidance literature:

Multi-step reaction with 3 steps

1: (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II) / toluene / 16 h / 50 °C / Inert atmosphere

2: tetrahydrofuran; water / 20 °C

3: tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate / methanol / 5 h / 20 °C / Inert atmosphere; Irradiation; Schlenk technique

With (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; In tetrahydrofuran; methanol; water; toluene;

DOI:10.1039/c3cc39235j

upstream raw materials:

1-ethynyl-4-(trifluoromethoxy)benzene

(E)-4,4,5,5-tetramethyl-2-(4-(trifluoromethoxy)styryl)-1,3,2-dioxaborolane

Togni's reagent II

4-trifluoromethoxycinnamic acid