(E)-4,4,5,5-tetramethyl-2-(4-(trifluoromethoxy)styryl)-1,3,2-dioxaborolane

Base Information

• Chemical Name: (E)-4,4,5,5-tetramethyl-2-(4-(trifluoromethoxy)styryl)-1,3,2-dioxaborolane
• CAS No.: 1425647-71-7
• Molecular Formula: C₁₅H₁₈BF₃O₃
• Molecular Weight: 314.112
• Mol file: 1425647-71-7.mol

Synonyms:(E)-4,4,5,5-tetramethyl-2-(4-(trifluoromethoxy)styryl)-1,3,2-dioxaborolane

Chemical Property of (E)-4,4,5,5-tetramethyl-2-(4-(trifluoromethoxy)styryl)-1,3,2-dioxaborolane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-4,4,5,5-tetramethyl-2-(4-(trifluoromethoxy)styryl)-1,3,2-dioxaborolane

There total 2 articles about (E)-4,4,5,5-tetramethyl-2-(4-(trifluoromethoxy)styryl)-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-ethynyl-4-(trifluoromethoxy)benzene (160542-02-9) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → (E)-4,4,5,5-tetramethyl-2-(4-(trifluoromethoxy)styryl)-1,3,2-dioxaborolane (1425647-71-7)

Guidance literature:

With (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); In toluene; at 50 ℃; for 16h; Inert atmosphere;

DOI:10.1039/c3cc39235j

Reference yield: 78.0%

1-ethynyl-4-(trifluoromethoxy)benzene (160542-02-9) + bis(pinacol)diborane (73183-34-3) → (E)-4,4,5,5-tetramethyl-2-(4-(trifluoromethoxy)styryl)-1,3,2-dioxaborolane (1425647-71-7)

Guidance literature:

With iron(III) oxide; caesium carbonate; In acetone; at 60 ℃; for 12h; Reagent/catalyst; stereoselective reaction; Sealed tube;

DOI:10.1055/s-0033-1341048

Reference yield: 80.0%

potassium hydrogenfluoride (1279123-63-5) + (E)-4,4,5,5-tetramethyl-2-(4-(trifluoromethoxy)styryl)-1,3,2-dioxaborolane (1425647-71-7) → potassium (E)-(2-(4-trifluoromethoxyphenyl)ethenyl)trifluoroborate

Guidance literature:

In tetrahydrofuran; water; at 20 ℃;

DOI:10.1039/c3cc39235j

upstream raw materials:

1-ethynyl-4-(trifluoromethoxy)benzene

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

bis(pinacol)diborane

Downstream raw materials:

(E)-1-(trifluoromethoxy)-4-(3,3,3-trifluoroprop-1-en-1-yl)benzene

(Z)-1-(3,3,3-trifluoroprop-1-enyl)-4-trifluoromethoxybenzene

(E)-2-(4-trifluoromethoxyphenyl)ethenylboronic acid