4-Nitro-benzoic acid (R)-1-isopropyl-4-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-butyl ester

Base Information

Chemical Name:4-Nitro-benzoic acid (R)-1-isopropyl-4-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-butyl ester
CAS No.:180611-39-6
Molecular Formula:C₂₁H₃₁NO₆
Molecular Weight:393.48
Hs Code.:

Synonyms:4-Nitro-benzoic acid (R)-1-isopropyl-4-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-butyl ester

Suppliers and Price of 4-Nitro-benzoic acid (R)-1-isopropyl-4-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-Nitro-benzoic acid (R)-1-isopropyl-4-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-Nitro-benzoic acid (R)-1-isopropyl-4-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-butyl ester

There total 10 articles about 4-Nitro-benzoic acid (R)-1-isopropyl-4-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 180611-40-9
(4R,5S)-4-((S)-4-hydroxy-5-methylhexyl)-2,2,5-trimethyl-1,3-dioxane

: 62-23-7
4-nitro-benzoic acid

: 180611-39-6
4-Nitro-benzoic acid (R)-1-isopropyl-4-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-butyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In benzene; for 2.5h; Ambient temperature;
DOI:10.1021/jo9608228

Reference yield:

: 160531-15-7
(S)-3-(benzyloxy)-4-methylpentanal

: 180611-39-6
4-Nitro-benzoic acid (R)-1-isopropyl-4-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) KOtBu / 1.) THF, 0 deg C, 1h, 2.) THF, -78 deg C, 1 h; 0 deg C, 1 h.

2: 1.) NiCl₂, NaBH₄, 2.) LiAlH₄ / 1.) MeOH, room temperature, 2 h, 2.) THF, -78 deg C, 3.5 h; room temperature, 30 min.

3: 1.) oxalyl chloride, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 10 min, 2.) -78 deg C, 10 min; 0 deg C, 15 min.

4: 1.) dibutylboron triflate, Et₃N / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) CH₂Cl₂, -78 deg C, 1.5 h; 0 deg C, 15 min.

5: 77 percent / Ph₃P, diethyl azodicarboxylate / benzene / 33 h / Ambient temperature

7: 94 percent / H₂ / Pd(OH)2 / dioxane / 1.8 h / 40 °C

8: 58 percent / Ph₃P, diethyl azodicarboxylate / benzene / 2.5 h / Ambient temperature

With sodium tetrahydroborate; lithium aluminium tetrahydride; oxalyl dichloride; di-n-butylboryl trifluoromethanesulfonate; potassium tert-butylate; hydrogen; dimethyl sulfoxide; triethylamine; triphenylphosphine; nickel dichloride; diethylazodicarboxylate; palladium dihydroxide; In 1,4-dioxane; benzene;
DOI:10.1021/jo9608228

Reference yield:

: 180611-34-1
(S)-5-Benzyloxy-6-methyl-heptan-1-ol

: 180611-39-6
4-Nitro-benzoic acid (R)-1-isopropyl-4-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) oxalyl chloride, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 10 min, 2.) -78 deg C, 10 min; 0 deg C, 15 min.

2: 1.) dibutylboron triflate, Et₃N / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) CH₂Cl₂, -78 deg C, 1.5 h; 0 deg C, 15 min.

3: 77 percent / Ph₃P, diethyl azodicarboxylate / benzene / 33 h / Ambient temperature

5: 94 percent / H₂ / Pd(OH)2 / dioxane / 1.8 h / 40 °C

6: 58 percent / Ph₃P, diethyl azodicarboxylate / benzene / 2.5 h / Ambient temperature

With oxalyl dichloride; di-n-butylboryl trifluoromethanesulfonate; hydrogen; dimethyl sulfoxide; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium dihydroxide; In 1,4-dioxane; benzene;
DOI:10.1021/jo9608228