4-((6bS,10aR)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl)butan-1-one

Base Information

Chemical Name:4-((6bS,10aR)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl)butan-1-one
CAS No.:313368-92-2
Molecular Formula:C₂₄H₂₈FN₃O
Molecular Weight:393.504
Hs Code.:

Synonyms:4-((6bS,10aR)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl)butan-1-one

Suppliers and Price of 4-((6bS,10aR)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl)butan-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-((6bS,10aR)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl)butan-1-one

Chemical Property:

Purity/Quality:: 95-1542%min ^*data from raw suppliers

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Technology Process of 4-((6bS,10aR)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl)butan-1-one

There total 15 articles about 4-((6bS,10aR)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl)butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: (cis)-4-(3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl)butan-1-one

: 313368-91-1
4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido-[3’,4’:4,5]-pyrrolo[1,2,3-de]quinoxalin-8-(7H)-yl)-1-(4-fluorophenyl)-1-butanone

: 313368-92-2
4-((6bS,10aR)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl)butan-1-one

Guidance literature:: With Chiral AD-H; In ethanol; Resolution of racemate;
DOI:10.1021/jm401958n

Reference yield:

: (cis)-3-methyl-2-oxo-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8-carboxylic acid ethyl ester

: 313368-91-1
4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido-[3’,4’:4,5]-pyrrolo[1,2,3-de]quinoxalin-8-(7H)-yl)-1-(4-fluorophenyl)-1-butanone

: 313368-92-2
4-((6bS,10aR)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl)butan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: borane-THF / tetrahydrofuran / 1 h / Inert atmosphere; Reflux

1.2: 0.5 h / Reflux; Inert atmosphere

2.1: potassium hydroxide / butan-1-ol / 5 h / Reflux

3.1: triethylamine; potassium iodide / 1,4-dioxane; toluene / 7 h / Reflux

4.1: Chiral AD-H / ethanol / Resolution of racemate

With borane-THF; triethylamine; potassium iodide; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; toluene; butan-1-ol;
DOI:10.1021/jm401958n

Reference yield:

: (cis)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido-[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxaline-8-carboxylic acid ethyl ester

: 313368-91-1
4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido-[3’,4’:4,5]-pyrrolo[1,2,3-de]quinoxalin-8-(7H)-yl)-1-(4-fluorophenyl)-1-butanone

: 313368-92-2
4-((6bS,10aR)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl)butan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / butan-1-ol / 5 h / Reflux

2: triethylamine; potassium iodide / 1,4-dioxane; toluene / 7 h / Reflux

3: Chiral AD-H / ethanol / Resolution of racemate

With triethylamine; potassium iodide; potassium hydroxide; In 1,4-dioxane; ethanol; toluene; butan-1-ol;
DOI:10.1021/jm401958n