1-(4-chloro-1-(2-methyl-3-nitrophenyl)-5H-pyridazino[4,5-b]indol-7-yl)ethanone

Base Information

Chemical Name:1-(4-chloro-1-(2-methyl-3-nitrophenyl)-5H-pyridazino[4,5-b]indol-7-yl)ethanone
CAS No.:1352836-73-7
Molecular Formula:C₁₉H₁₃ClN₄O₃
Molecular Weight:380.79
Hs Code.:

Synonyms:1-(4-chloro-1-(2-methyl-3-nitrophenyl)-5H-pyridazino[4,5-b]indol-7-yl)ethanone

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Chemical Property of 1-(4-chloro-1-(2-methyl-3-nitrophenyl)-5H-pyridazino[4,5-b]indol-7-yl)ethanone

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Technology Process of 1-(4-chloro-1-(2-methyl-3-nitrophenyl)-5H-pyridazino[4,5-b]indol-7-yl)ethanone

There total 5 articles about 1-(4-chloro-1-(2-methyl-3-nitrophenyl)-5H-pyridazino[4,5-b]indol-7-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352836-71-5
7-acetyl-1-(2-methyl-3-nitrophenyl)-3H-pyridazino[4,5-b]indol-4(5H)-one

: 1352836-73-7
1-(4-chloro-1-(2-methyl-3-nitrophenyl)-5H-pyridazino[4,5-b]indol-7-yl)ethanone

Guidance literature:: 7-acetyl-1-(2-methyl-3-nitrophenyl)-3H-pyridazino[4,5-b]indol-4(5H)-one; With trichlorophosphate; at 110 ℃; for 1h; Inert atmosphere;

With sodium hydrogencarbonate; In water; ethyl acetate; Cooling with ice;

Reference yield:

: 103858-53-3
ethyl 6-bromo-1H-indole-2-carboxylate

: 1352836-73-7
1-(4-chloro-1-(2-methyl-3-nitrophenyl)-5H-pyridazino[4,5-b]indol-7-yl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: tin(IV) chloride / dichloromethane / 0.75 h / 0 - 20 °C

1.2: 4.33 h / 20 °C

2.1: hydrazine hydrate / ethanol / 16 h / Reflux

3.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 24 h / 95 °C

3.2: 1.5 h / 60 °C

3.3: pH 4 - 5

4.1: trichlorophosphate / 1 h / 110 °C / Inert atmosphere

4.2: Cooling with ice

With tin(IV) chloride; hydrazine hydrate; triethylamine; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; ethanol; dichloromethane;

Reference yield:

: 39053-41-3
2-methyl-3-nitrobenzoyl chloride

: 1352836-73-7
1-(4-chloro-1-(2-methyl-3-nitrophenyl)-5H-pyridazino[4,5-b]indol-7-yl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: tin(IV) chloride / dichloromethane / 0.75 h / 0 - 20 °C

1.2: 4.33 h / 20 °C

2.1: hydrazine hydrate / ethanol / 16 h / Reflux

3.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 24 h / 95 °C

3.2: 1.5 h / 60 °C

3.3: pH 4 - 5

4.1: trichlorophosphate / 1 h / 110 °C / Inert atmosphere

4.2: Cooling with ice

With tin(IV) chloride; hydrazine hydrate; triethylamine; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; ethanol; dichloromethane;