5-chloro-N-(1,1-dioxo-1H-1λ⁶-benzo[b]thiophen-6-yl)-2-hydroxybenzamide

Base Information

Chemical Name:5-chloro-N-(1,1-dioxo-1H-1λ⁶-benzo[b]thiophen-6-yl)-2-hydroxybenzamide
CAS No.:1430330-65-6
Molecular Formula:C₁₅H₁₀ClNO₄S
Molecular Weight:335.768
Hs Code.:

5-chloro-N-(1,1-dioxo-1H-1λ<sup>6</sup>-benzo[b]thiophen-6-yl)-2-hydroxybenzamide

Synonyms:5-chloro-N-(1,1-dioxo-1H-1λ⁶-benzo[b]thiophen-6-yl)-2-hydroxybenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-chloro-N-(1,1-dioxo-1H-1λ⁶-benzo[b]thiophen-6-yl)-2-hydroxybenzamide

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Technology Process of 5-chloro-N-(1,1-dioxo-1H-1λ⁶-benzo[b]thiophen-6-yl)-2-hydroxybenzamide

There total 2 articles about 5-chloro-N-(1,1-dioxo-1H-1λ⁶-benzo[b]thiophen-6-yl)-2-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 15216-81-6
5-chloro-2-hydroxybenzoyl chloride

: 20503-40-6
1,1-dioxo-1H-1λ6-benzo[b]thiophen-6-ylamine

: 1430330-65-6
5-chloro-N-(1,1-dioxo-1H-1λ⁶-benzo[b]thiophen-6-yl)-2-hydroxybenzamide

Guidance literature:: 5-chloro-2-hydroxybenzoyl chloride; 1,1-dioxo-1H-1λ6-benzo[b]thiophen-6-ylamine; With pyridine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 24h; Inert atmosphere;

With lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.01.023

Reference yield:

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 1430330-65-6
5-chloro-N-(1,1-dioxo-1H-1λ⁶-benzo[b]thiophen-6-yl)-2-hydroxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / toluene / 110 °C / Inert atmosphere

2.1: pyridine / N,N-dimethyl-formamide / 24 h / 0 - 20 °C / Inert atmosphere

2.2: 0.5 h / 0 °C / Inert atmosphere

With pyridine; thionyl chloride; In N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2013.01.023

Reference yield: 77.0%

: 371-62-0
2-fluoroethanol

: 1430330-65-6
5-chloro-N-(1,1-dioxo-1H-1λ⁶-benzo[b]thiophen-6-yl)-2-hydroxybenzamide

: 1617518-13-4
5-chloro-N-(1,1-dioxo-1H-1λ⁶-benzo[b]thiophen-6-yl)-2-(2-fluoroethoxy)benzamide

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.05.049