5-Chloro-2-hydroxybenzoyl chloride

Base Information

• Chemical Name: 5-Chloro-2-hydroxybenzoyl chloride
• CAS No.: 15216-81-6
• Molecular Formula: C7H4Cl2O2
• Molecular Weight: 191.014
• DSSTox Substance ID: DTXSID50511797
• Nikkaji Number: J1.028.499F
• Wikidata: Q82370767
• Mol file: 15216-81-6.mol

Synonyms:5-chloro-2-hydroxybenzoyl chloride;15216-81-6;Benzoyl chloride, 5-chloro-2-hydroxy-;5-chloro-salicyloyl chloride;SCHEMBL4955043;5-chloro-2-hydroxybenzoylchloride;DTXSID50511797;NANJQJRZYOVMLF-UHFFFAOYSA-N;5-chloro-2-hydroxy-benzoyl chloride;MFCD11169665;AKOS009216566;AS-63290;CS-0080010;W16064

Chemical Property of 5-Chloro-2-hydroxybenzoyl chloride

Chemical Property:

• XLogP3: 4.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 189.9588348
• Heavy Atom Count: 11
• Complexity: 161

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)C(=O)Cl)O

Technology Process of 5-Chloro-2-hydroxybenzoyl chloride

There total 1 articles about 5-Chloro-2-hydroxybenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.9%

sodium 5-chloro-2-hydroxybenzoate (10265-67-5) → 5-chloro-2-hydroxybenzoyl chloride (15216-81-6)

Guidance literature:

With thionyl chloride; In benzene; at 60 ℃; for 3h;

Reference yield: 95.0%

5-chloro-2-hydroxybenzoyl chloride (15216-81-6) + 4-(benzothiazol-2-ylsulfanyl)-3-trifluoromethyl-phenylamine → N-[4-(benzothiazol-2-yl)sulfanyl-3-(trifluoromethyl)phenyl]-5-chloro-2hydroxybenzamide

Guidance literature:

With 4-vinylpyridine; silver benzoate; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/S0040-4039(99)01972-3

Reference yield: 95.0%

5-chloro-2-hydroxybenzoyl chloride (15216-81-6) + 3-trifluoromethyl-4-(4-trifluoromethylsulfanyl-phenoxy)-phenylamine → 5-chloro-2-hydroxy-N-(3-trifluoromethyl-4-{[4-(trifluoromethyl)sulfanyl]phenoxy}-phenyl)benzamide

Guidance literature:

With 4-vinylpyridine; silver benzoate; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/S0040-4039(99)01972-3

upstream raw materials:

sodium 5-chloro-2-hydroxybenzoate

Downstream raw materials:

5-chlorosalicyclaldehyde

Carbonic acid 4-chloro-2-(4-chloro-phenylcarbamoyl)-phenyl ester ethyl ester

Carbonic acid 4-chloro-2-(2-chloro-phenylcarbamoyl)-phenyl ester ethyl ester

4-(5-Chloro-2-hydroxybenzoyl)-1-(4-nitrophenyl)piperazine