1-{4'-[1-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-[1,2,3]-triazol-4-yl]biphenyl-4-yl}cyclopropanecarboxylic acid methyl ester

Base Information

Chemical Name:1-{4'-[1-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-[1,2,3]-triazol-4-yl]biphenyl-4-yl}cyclopropanecarboxylic acid methyl ester
CAS No.:1396008-17-5
Molecular Formula:C₂₉H₂₈N₄O₄
Molecular Weight:496.566
Hs Code.:

Synonyms:1-{4'-[1-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-[1,2,3]-triazol-4-yl]biphenyl-4-yl}cyclopropanecarboxylic acid methyl ester

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Chemical Property of 1-{4'-[1-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-[1,2,3]-triazol-4-yl]biphenyl-4-yl}cyclopropanecarboxylic acid methyl ester

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Technology Process of 1-{4'-[1-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-[1,2,3]-triazol-4-yl]biphenyl-4-yl}cyclopropanecarboxylic acid methyl ester

There total 6 articles about 1-{4'-[1-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-[1,2,3]-triazol-4-yl]biphenyl-4-yl}cyclopropanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.8%

: 1396008-13-1
[5-(4-bromo-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]carbamic acid (R)-1-phenyl-ethyl ester

: 1396007-85-4
1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarboxylic acid methyl ester

: 1396008-17-5
1-{4'-[1-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-[1,2,3]-triazol-4-yl]biphenyl-4-yl}cyclopropanecarboxylic acid methyl ester

Guidance literature:: With potassium phosphate; palladium diacetate; XPhos; In water; toluene; at 95 ℃; for 3h; Sealed tube;

Reference yield:

: 766-96-1
4-bromo-1-ethynylbenzene

: 1396008-17-5
1-{4'-[1-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-[1,2,3]-triazol-4-yl]biphenyl-4-yl}cyclopropanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -70 °C

1.2: 2 h / -70 - 20 °C

2.1: benzene / 4 h / Reflux

3.1: tetrabutyl ammonium fluoride; water / tetrahydrofuran / 0.17 h / 0 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

5.1: diphenyl phosphoryl azide; triethylamine / toluene / 2 h / 90 °C

6.1: XPhos; palladium diacetate; potassium phosphate / toluene; water / 3 h / 95 °C / Sealed tube

With potassium phosphate; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; water; palladium diacetate; triethylamine; lithium hydroxide; lithium diisopropyl amide; XPhos; In tetrahydrofuran; water; toluene; benzene;

Reference yield:

: (4-bromo-phenyl)propynoic acid ethyl ester

: 1396008-17-5
1-{4'-[1-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-[1,2,3]-triazol-4-yl]biphenyl-4-yl}cyclopropanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: benzene / 4 h / Reflux

2: tetrabutyl ammonium fluoride; water / tetrahydrofuran / 0.17 h / 0 °C

3: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

4: diphenyl phosphoryl azide; triethylamine / toluene / 2 h / 90 °C

5: XPhos; palladium diacetate; potassium phosphate / toluene; water / 3 h / 95 °C / Sealed tube

With potassium phosphate; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; water; palladium diacetate; triethylamine; lithium hydroxide; XPhos; In tetrahydrofuran; water; toluene; benzene;