3-fluoro-1-((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyrido[3',2': 4,5]pyrimido[1,6-a]indol-6-yl)methyl)azetidin-1-ium methanesulfonate

Base Information

Chemical Name:3-fluoro-1-((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyrido[3',2': 4,5]pyrimido[1,6-a]indol-6-yl)methyl)azetidin-1-ium methanesulfonate
CAS No.:1621887-78-2
Molecular Formula:CH₄O₃S*C₃₆H₂₉F₃N₆O₄S
Molecular Weight:794.832
Hs Code.:

3-fluoro-1-((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyrido[3',2': 4,5]pyrimido[1,6-a]indol-6-yl)methyl)azetidin-1-ium methanesulfonate

Synonyms:3-fluoro-1-((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyrido[3',2': 4,5]pyrimido[1,6-a]indol-6-yl)methyl)azetidin-1-ium methanesulfonate

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Chemical Property of 3-fluoro-1-((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyrido[3',2': 4,5]pyrimido[1,6-a]indol-6-yl)methyl)azetidin-1-ium methanesulfonate

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Technology Process of 3-fluoro-1-((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyrido[3',2': 4,5]pyrimido[1,6-a]indol-6-yl)methyl)azetidin-1-ium methanesulfonate

There total 10 articles about 3-fluoro-1-((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyrido[3',2': 4,5]pyrimido[1,6-a]indol-6-yl)methyl)azetidin-1-ium methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 75-75-2,98527-29-8
methanesulfonic acid

: 1621887-18-0
5-(11-fluoro-6-((3-fluoroazetidin-1-yl)methyl)pyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

: 1621887-78-2
3-fluoro-1-((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyrido[3',2': 4,5]pyrimido[1,6-a]indol-6-yl)methyl)azetidin-1-ium methanesulfonate

Guidance literature:: In methanol;

Reference yield:

: 400777-06-2
6-chloro-2-iodopyridin-3-amine

: 1621887-78-2
3-fluoro-1-((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyrido[3',2': 4,5]pyrimido[1,6-a]indol-6-yl)methyl)azetidin-1-ium methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; caesium carbonate / water; 1,4-dioxane / 70 °C / Inert atmosphere

2: dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; caesium carbonate / water; 1,4-dioxane / 90 °C / Inert atmosphere

3: trifluoroacetic acid / 1,4-dioxane / 3 h / 85 °C

4: caesium carbonate / N,N-dimethyl-formamide / 50 °C

5: methanol

With dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; caesium carbonate; trifluoroacetic acid; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; 1: |Suzuki Coupling / 2: |Suzuki Coupling;

Reference yield:

: 1256359-96-2
4-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole

: 1621887-78-2
3-fluoro-1-((11-fluoro-2-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)pyrido[3',2': 4,5]pyrimido[1,6-a]indol-6-yl)methyl)azetidin-1-ium methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; caesium carbonate / water; 1,4-dioxane / 70 °C / Inert atmosphere

2: dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; caesium carbonate / water; 1,4-dioxane / 90 °C / Inert atmosphere

3: trifluoroacetic acid / 1,4-dioxane / 3 h / 85 °C

4: caesium carbonate / N,N-dimethyl-formamide / 50 °C

5: methanol

With dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; caesium carbonate; trifluoroacetic acid; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; 1: |Suzuki Coupling / 2: |Suzuki Coupling;