3-(3-isopropoxy-4-methoxybenzene)-1-(3,4,5-trimethoxybenzene)-2-alkynylacetone

Base Information

Chemical Name:3-(3-isopropoxy-4-methoxybenzene)-1-(3,4,5-trimethoxybenzene)-2-alkynylacetone
CAS No.:445483-11-4
Molecular Formula:C₂₂H₂₄O₆
Molecular Weight:384.429
Hs Code.:

Synonyms:3-(3-isopropoxy-4-methoxybenzene)-1-(3,4,5-trimethoxybenzene)-2-alkynylacetone

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Chemical Property of 3-(3-isopropoxy-4-methoxybenzene)-1-(3,4,5-trimethoxybenzene)-2-alkynylacetone

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Technology Process of 3-(3-isopropoxy-4-methoxybenzene)-1-(3,4,5-trimethoxybenzene)-2-alkynylacetone

There total 5 articles about 3-(3-isopropoxy-4-methoxybenzene)-1-(3,4,5-trimethoxybenzene)-2-alkynylacetone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 439585-86-1
4-ethynyl-2-isopropoxy-1-methoxybenzene

: 445483-11-4
3-(3-isopropoxy-4-methoxybenzene)-1-(3,4,5-trimethoxybenzene)-2-alkynylacetone

Guidance literature:: 4-ethynyl-2-isopropoxy-1-methoxybenzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

3,4,5-trimethoxy-benzaldehyde; In tetrahydrofuran; at -78 - 20 ℃; for 2.5h; Reagent/catalyst; Solvent; Inert atmosphere;

Reference yield: 66.0%

: 4521-61-3
3,4,5-Trimethoxybenzoyl chloride

: 215715-43-8
β,β-dibromo-3-isopropoxy-4-methoxystyrene

: 445483-11-4
3-(3-isopropoxy-4-methoxybenzene)-1-(3,4,5-trimethoxybenzene)-2-alkynylacetone

Guidance literature:: β,β-dibromo-3-isopropoxy-4-methoxystyrene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 18 ℃;

3,4,5-Trimethoxybenzoyl chloride; In tetrahydrofuran; hexane; at -78 - 18 ℃; Further stages.;
DOI:10.1016/j.bmc.2007.02.006

Reference yield:

: 34123-66-5
O-isopropylisovanillin

: 445483-11-4
3-(3-isopropoxy-4-methoxybenzene)-1-(3,4,5-trimethoxybenzene)-2-alkynylacetone

Guidance literature:: Multi-step reaction with 2 steps

1.1: Ph₃P; Zn / CH₂Cl₂

2.1: n-butyllithium / tetrahydrofuran; hexane / -78 - 18 °C

2.2: 66 percent / tetrahydrofuran; hexane / -78 - 18 °C

With n-butyllithium; triphenylphosphine; zinc; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.bmc.2007.02.006