(S)-4-(5-amino-4-(2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxyphenoxy)butyl 4-methylpiperazine-1-carbodithioate

Base Information

Chemical Name:(S)-4-(5-amino-4-(2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxyphenoxy)butyl 4-methylpiperazine-1-carbodithioate
CAS No.:1227458-50-5
Molecular Formula:C₂₇H₄₄N₄O₃S₄
Molecular Weight:600.935
Hs Code.:

Synonyms:(S)-4-(5-amino-4-(2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxyphenoxy)butyl 4-methylpiperazine-1-carbodithioate

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Chemical Property of (S)-4-(5-amino-4-(2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxyphenoxy)butyl 4-methylpiperazine-1-carbodithioate

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Technology Process of (S)-4-(5-amino-4-(2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxyphenoxy)butyl 4-methylpiperazine-1-carbodithioate

There total 3 articles about (S)-4-(5-amino-4-(2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxyphenoxy)butyl 4-methylpiperazine-1-carbodithioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1227458-49-2
(S)-4-(4-(2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxy-5-nitrophenoxy)butyl 4-methylpiperazine-1-carbodithioate

: 1227458-50-5
(S)-4-(5-amino-4-(2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxyphenoxy)butyl 4-methylpiperazine-1-carbodithioate

Guidance literature:: With tin(II) chloride dihdyrate; In methanol; for 5h; Reflux;
DOI:10.1016/j.bioorg.2015.01.002

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1227458-50-5
(S)-4-(5-amino-4-(2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxyphenoxy)butyl 4-methylpiperazine-1-carbodithioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium phosphate / acetone / 1 h / 10 °C

1.2: 12 h / 20 °C

2.1: tin(II) chloride hydrate / methanol / 5 h / Reflux

2.2: pH 8

With potassium phosphate; tin(II) chloride hydrate; In methanol; acetone;

Reference yield:

: 343308-56-5
(2S)-N-[4-(4-bromobutyl)oxy-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethylthioacetal

: 1227458-50-5
(S)-4-(5-amino-4-(2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxyphenoxy)butyl 4-methylpiperazine-1-carbodithioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium phosphate / acetone / 1 h / 10 °C

1.2: 12 h / 20 °C

2.1: tin(II) chloride hydrate / methanol / 5 h / Reflux

2.2: pH 8

With potassium phosphate; tin(II) chloride hydrate; In methanol; acetone;