1227458-49-2

Upstream product

• 109-01-3 1-methyl-piperazine 
• 75-15-0 carbon disulfide 
• 343308-56-5 (2S)-N-[4-(4-bromobutyl)oxy-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethylthioacetal 

Downstream Products

• 1227458-50-5 (S)-4-(5-amino-4-(2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxyphenoxy)butyl 4-methylpiperazine-1-carbodithioate 

Relevant academic research and scientific papers

Dithiocarbamate/piperazine bridged pyrrolobenzodiazepines as DNA-minor groove binders: Synthesis, DNA-binding affinity and cytotoxic activity

A new series of C8-linked dithiocarbamate/piperazine bridged pyrrolo[2,1-c][1,4]benzodiazepine conjugates (5a-c, 6a,b) have been synthesized and evaluated for their cytotoxic potential and DNA-binding ability. The representative conjugates 5a and 5b have

NOVEL PYRROLO[2,1-C][1,4] BENZODIAZEPINE DERIVATIVES WITH DITHIOCARBAMATE SIDE CHAINS AND PROCESS FOR THE PREPARATION THEREOF

The present invention provides synthesis and in vitro anticancer activity of novel pyrrolo[2,1-c][1,4]benzodiazepine derivatives with dithiocarbamate side chains. The present invention also relates to a process for the preparation of new pyrrolo[2,1-c][1,4]benzodiazepine derivatives with dithiocarbamate side chains of general formula (A) and a process for the preparation thereof.

NOVEL PYRROIOL2,L-CU1.41BENZODIAZEPINE DERIVATIVES WITH DITHIOCARBAMATE SIDE CHAINS AND PROCESS FOR THE PREPARATION THEREOF

The present invention provides synthesis and in vitro anticancer activity of novel pyrrolo[2,1-c][1,4]benzodiazepine derivatives with dithiocarbamate side chains. The present invention also relates to a process for the preparation of new pyrrolo[2,1-c][1,4]benzodiazepine derivatives with dithiocarbamate side chains of general formula (A) and a process for the preparation thereof.