2-[(2S)-2-(3,4-dichlorophenyl)-4-hydroxybutyl]-1-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine-5-carbonitrile

Base Information

Chemical Name:2-[(2S)-2-(3,4-dichlorophenyl)-4-hydroxybutyl]-1-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine-5-carbonitrile
CAS No.:711020-23-4
Molecular Formula:C₂₃H₁₈Cl₂N₂O₃
Molecular Weight:441.314
Hs Code.:

Synonyms:2-[(2S)-2-(3,4-dichlorophenyl)-4-hydroxybutyl]-1-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine-5-carbonitrile

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Chemical Property of 2-[(2S)-2-(3,4-dichlorophenyl)-4-hydroxybutyl]-1-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine-5-carbonitrile

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Technology Process of 2-[(2S)-2-(3,4-dichlorophenyl)-4-hydroxybutyl]-1-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine-5-carbonitrile

There total 4 articles about 2-[(2S)-2-(3,4-dichlorophenyl)-4-hydroxybutyl]-1-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: acetic acid 4-(5-cyano-1-oxo-1H-naphtho[1,2-e][1,3]oxazin-2-yl)-3-(3,4-dichloro-phenyl)-butyl ester

: 711020-23-4
2-[(2S)-2-(3,4-dichlorophenyl)-4-hydroxybutyl]-1-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine-5-carbonitrile

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 2.75h;
DOI:10.1016/j.bmc.2004.03.015

Reference yield:

: 263388-13-2
2-Methoxy-3-cyano-1-naphthoyl Chloride

: 711020-23-4
2-[(2S)-2-(3,4-dichlorophenyl)-4-hydroxybutyl]-1-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine-5-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / aq. NaOH / CH₂Cl₂ / 0 - 20 °C

2: 89 percent / magnesium; iodine / benzene; diethyl ether / 1 h / Heating

3: sulfuric acid / CHCl₃ / 5 - 20 °C

4: 0.28 g / NaOH / tetrahydrofuran; H₂O; methanol / 2.75 h / 20 °C

With sodium hydroxide; sulfuric acid; iodine; magnesium; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; water; benzene;
DOI:10.1016/j.bmc.2004.03.015

Reference yield:

: 263862-54-0
3-cyano-N-[(2S)-2-(3,4-dichlorophenyl)-4-hydroxybutyl]-2-methoxy-1-naphthamide

: 711020-23-4
2-[(2S)-2-(3,4-dichlorophenyl)-4-hydroxybutyl]-1-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine-5-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / magnesium; iodine / benzene; diethyl ether / 1 h / Heating

2: sulfuric acid / CHCl₃ / 5 - 20 °C

3: 0.28 g / NaOH / tetrahydrofuran; H₂O; methanol / 2.75 h / 20 °C

With sodium hydroxide; sulfuric acid; iodine; magnesium; In tetrahydrofuran; methanol; diethyl ether; chloroform; water; benzene;
DOI:10.1016/j.bmc.2004.03.015