3-cyano-N-[(2S)-2-(3,4-dichlorophenyl)-4-hydroxybutyl]-2-methoxy-1-naphthamide

Base Information

• Chemical Name: 3-cyano-N-[(2S)-2-(3,4-dichlorophenyl)-4-hydroxybutyl]-2-methoxy-1-naphthamide
• CAS No.: 263862-54-0
• Molecular Formula: C₂₃H₂₀Cl₂N₂O₃
• Molecular Weight: 443.329

Synonyms:3-cyano-N-[(2S)-2-(3,4-dichlorophenyl)-4-hydroxybutyl]-2-methoxy-1-naphthamide

Chemical Property of 3-cyano-N-[(2S)-2-(3,4-dichlorophenyl)-4-hydroxybutyl]-2-methoxy-1-naphthamide

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Technology Process of 3-cyano-N-[(2S)-2-(3,4-dichlorophenyl)-4-hydroxybutyl]-2-methoxy-1-naphthamide

There total 1 articles about 3-cyano-N-[(2S)-2-(3,4-dichlorophenyl)-4-hydroxybutyl]-2-methoxy-1-naphthamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-Methoxy-3-cyano-1-naphthoyl Chloride (263388-13-2) + (S)-2-(3,4-dichlorophenyl)-4-hydroxybutylamine (160707-16-4,135936-36-6) → 3-cyano-N-[(2S)-2-(3,4-dichlorophenyl)-4-hydroxybutyl]-2-methoxy-1-naphthamide (263862-54-0)

Guidance literature:

With sodium hydroxide; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2004.03.015

Reference yield: 94.0%

tert-butyldimethylsilyl chloride (18162-48-6) + 3-cyano-N-[(2S)-2-(3,4-dichlorophenyl)-4-hydroxybutyl]-2-methoxy-1-naphthamide (263862-54-0) → N-[(2S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(3,4-dichlorophenyl)butyl]-3-cyano-2-methoxy-1-naphthamide (263862-55-1)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmc.2004.03.015

Reference yield: 89.0%

3-cyano-N-[(2S)-2-(3,4-dichlorophenyl)-4-hydroxybutyl]-2-methoxy-1-naphthamide (263862-54-0) → 3-cyano-N-[(2S)-2-(3,4-dichlorophenyl)-4-hydroxybutyl]-2-hydroxy-1-naphthamide (711020-22-3)

Guidance literature:

With iodine; magnesium; In diethyl ether; benzene; for 1h; Heating;

DOI:10.1016/j.bmc.2004.03.015

upstream raw materials:

2-Methoxy-3-cyano-1-naphthoyl Chloride

(S)-2-(3,4-dichlorophenyl)-4-hydroxybutylamine

Downstream raw materials:

N-[(2S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(3,4-dichlorophenyl)butyl]-3-cyano-2-methoxy-1-naphthamide

3-cyano-N-[(2S)-2-(3,4-dichlorophenyl)-4-hydroxybutyl]-2-hydroxy-1-naphthamide

2-[(2S)-2-(3,4-dichlorophenyl)-4-oxobutyl]-1-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine-5-carbonitrile

2-[(2S)-2-(3,4-dichlorophenyl)-4-hydroxybutyl]-1-oxo-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine-5-carbonitrile

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