N-<2-<(benzyloxycarbonyl)amino>-2-<(methylthio)ethyl>hydrocinnamoyl>-L-norleucine benzyl ester

Base Information

Chemical Name:N-<2-<(benzyloxycarbonyl)amino>-2-<(methylthio)ethyl>hydrocinnamoyl>-L-norleucine benzyl ester
CAS No.:116650-51-2
Molecular Formula:C₃₃H₄₀N₂O₅S
Molecular Weight:576.757
Hs Code.:

Synonyms:N-<2-<(benzyloxycarbonyl)amino>-2-<(methylthio)ethyl>hydrocinnamoyl>-L-norleucine benzyl ester

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Chemical Property of N-<2-<(benzyloxycarbonyl)amino>-2-<(methylthio)ethyl>hydrocinnamoyl>-L-norleucine benzyl ester

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Technology Process of N-<2-<(benzyloxycarbonyl)amino>-2-<(methylthio)ethyl>hydrocinnamoyl>-L-norleucine benzyl ester

There total 4 articles about N-<2-<(benzyloxycarbonyl)amino>-2-<(methylthio)ethyl>hydrocinnamoyl>-L-norleucine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 63219-54-5
nLeu-OBzl

: 114155-68-9
2-<(benzyloxycarbonyl)amino>-2-<(methylthio)ethyl>hydrocinnamic acid

: 116650-51-2
N-<2-<(benzyloxycarbonyl)amino>-2-<(methylthio)ethyl>hydrocinnamoyl>-L-norleucine benzyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; for 6h;
DOI:10.1021/jm00402a021

Reference yield:

: 116650-55-6
α-benzyl-α-amino-γ-butyrolactone

: 116650-51-2
N-<2-<(benzyloxycarbonyl)amino>-2-<(methylthio)ethyl>hydrocinnamoyl>-L-norleucine benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / sodium carbonate / tetrahydrofuran / 18 h / Ambient temperature

2: 88 percent / hexamethylphosphoric acid triamide / 96 h / Ambient temperature

3: 86 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / CH₂Cl₂ / 6 h

With sodium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1021/jm00402a021

Reference yield:

: 100-52-7
benzaldehyde

: 116650-51-2
N-<2-<(benzyloxycarbonyl)amino>-2-<(methylthio)ethyl>hydrocinnamoyl>-L-norleucine benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / Et₃N, MgSO₄ / CH₂Cl₂ / 20 h / Ambient temperature

2: 1.) lithium diisopropylamide / 1) THF, hexane, -78 deg C, 15 min; 2) THF, hexane room temperature, 24 h

3: 99 percent / sodium carbonate / tetrahydrofuran / 18 h / Ambient temperature

4: 88 percent / hexamethylphosphoric acid triamide / 96 h / Ambient temperature

5: 86 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / CH₂Cl₂ / 6 h

With sodium carbonate; magnesium sulfate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1021/jm00402a021