tert-butyl 4-(2-hydroxy-1-methylethyl)-3-nitrobenzoate

Base Information

• Chemical Name: tert-butyl 4-(2-hydroxy-1-methylethyl)-3-nitrobenzoate
• CAS No.: 702643-08-1
• Molecular Formula: C₁₄H₁₉NO₅
• Molecular Weight: 281.309
• Mol file: 702643-08-1.mol

Synonyms:tert-butyl 4-(2-hydroxy-1-methylethyl)-3-nitrobenzoate

Chemical Property of tert-butyl 4-(2-hydroxy-1-methylethyl)-3-nitrobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(2-hydroxy-1-methylethyl)-3-nitrobenzoate

There total 2 articles about tert-butyl 4-(2-hydroxy-1-methylethyl)-3-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + tert-butyl 3-nitro-4-ethyl-benzoate (702642-66-8) → tert-butyl 4-(2-hydroxy-1-methylethyl)-3-nitrobenzoate (702643-08-1)

Guidance literature:

With potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃; for 1h;

DOI:10.1002/hlca.200590067

Reference yield:

4-Ethyl-3-nitrobenzoic acid (103440-95-5) → tert-butyl 4-(2-hydroxy-1-methylethyl)-3-nitrobenzoate (702643-08-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / N,N-dicyclohexylcarbodiimide; N,N-dimethylpyridin-4-amine / CH₂Cl₂ / 3 h / 20 °C

2: 100 percent / t-BuOK / dimethylsulfoxide / 1 h / 20 °C

With dmap; potassium tert-butylate; dicyclohexyl-carbodiimide; In dichloromethane; dimethyl sulfoxide;

DOI:10.1002/hlca.200590067

Reference yield: 100.0%

tert-butyl 4-(2-hydroxy-1-methylethyl)-3-nitrobenzoate (702643-08-1) + trichloromethyl chloroformate (503-38-8) → C15H18ClNO6 (748789-31-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1002/hlca.200490060

upstream raw materials:

formaldehyd

tert-butyl 3-nitro-4-ethyl-benzoate

4-Ethyl-3-nitrobenzoic acid

Downstream raw materials:

C₁₅H₁₈ClNO₆

tert-butyl 4-{2-[(2-methoxyethoxy)methoxy]-1-methylethyl}-3-nitrobenzoate

4-{2-[(2-methoxyethoxy)methoxy]-1-methylethyl}-3-nitrobenzoic acid

9-oxo-9H-thioxanthen-2-yl 4-(2-hydroxy-1-methylethyl)-3-nitrobenzoate