N-{5-chloro-4'-[2-cyclopropylimino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-acetamide

Base Information

Chemical Name:N-{5-chloro-4'-[2-cyclopropylimino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-acetamide
CAS No.:1352873-93-8
Molecular Formula:C₃₃H₂₈ClN₅O
Molecular Weight:546.071
Hs Code.:

Synonyms:N-{5-chloro-4'-[2-cyclopropylimino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-acetamide

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Chemical Property of N-{5-chloro-4'-[2-cyclopropylimino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-acetamide

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Technology Process of N-{5-chloro-4'-[2-cyclopropylimino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-acetamide

There total 11 articles about N-{5-chloro-4'-[2-cyclopropylimino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1352874-62-4
N-[5-chloro-4'-(2-cyclopropylamino-benzoimidazol-1-yl)-biphenyl-2-yl]-acetamide

: 76-05-1
trifluoroacetic acid

: 220499-13-8
tert-butyl 4-(bromomethyl)-1H-1-indolecarboxylate

: 1352873-93-8
N-{5-chloro-4'-[2-cyclopropylimino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-acetamide

Guidance literature:: N-[5-chloro-4'-(2-cyclopropylamino-benzoimidazol-1-yl)-biphenyl-2-yl]-acetamide; tert-butyl 4-(bromomethyl)-1H-1-indolecarboxylate; With potassium iodide; In acetonitrile; at 110 ℃; for 0.166667h;

trifluoroacetic acid; for 0.166667h;

Reference yield:

: 106-40-1
4-bromo-aniline

: 1352873-93-8
N-{5-chloro-4'-[2-cyclopropylimino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / 4 h / 150 °C / Microwave irradiaton

1.2: 0.25 h

2.1: tin(II) chloride dihdyrate / ethanol / 2.83 h / 70 °C

3.1: water; acetonitrile / 18 h / 20 °C

4.1: dichloromethane / 1 h / Reflux

5.1: trichlorophosphate / 3 h / Reflux

5.2: 20 °C

6.1: hydrogenchloride / water; isopropyl alcohol / 2 h / 150 °C / Microwave irradiation

7.1: sodium carbonate / [1,4-bis(diphenylphosphino)butane] palladium(ll) dichloride / 1,2-dimethoxyethane; water / 0.27 h / 150 °C / Microwave irradiation

8.1: potassium iodide / acetonitrile / 0.17 h / 110 °C

8.2: 0.17 h

With hydrogenchloride; tin(II) chloride dihdyrate; sodium carbonate; triethylamine; potassium iodide; trichlorophosphate; [1,4-bis(diphenylphosphino)butane] palladium(ll) dichloride; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; isopropyl alcohol; acetonitrile;

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1352873-93-8
N-{5-chloro-4'-[2-cyclopropylimino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / 4 h / 150 °C / Microwave irradiaton

1.2: 0.25 h

2.1: tin(II) chloride dihdyrate / ethanol / 2.83 h / 70 °C

3.1: water; acetonitrile / 18 h / 20 °C

4.1: dichloromethane / 1 h / Reflux

5.1: trichlorophosphate / 3 h / Reflux

5.2: 20 °C

6.1: hydrogenchloride / water; isopropyl alcohol / 2 h / 150 °C / Microwave irradiation

7.1: sodium carbonate / [1,4-bis(diphenylphosphino)butane] palladium(ll) dichloride / 1,2-dimethoxyethane; water / 0.27 h / 150 °C / Microwave irradiation

8.1: potassium iodide / acetonitrile / 0.17 h / 110 °C

8.2: 0.17 h

With hydrogenchloride; tin(II) chloride dihdyrate; sodium carbonate; triethylamine; potassium iodide; trichlorophosphate; [1,4-bis(diphenylphosphino)butane] palladium(ll) dichloride; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; isopropyl alcohol; acetonitrile;